Genetics of longevity. Data from the studies on Sicilian centenarians

Immunity & Ageing

Table 1 Main modifications of B cells and B cells products in elderly human observed in our laboratory

B cells or B cells products	Changes	References
Total B cells (percentage)	↓	[9]
CD19⁺CD5⁺ B1 cells (percentage and absolute number)	↓	[10]
IgG, IgA	↑	[11]
IgM, IgD	↓	[11]
IgE	=	[11]
Autoantibodies	↑	[12]
Naive (IgD⁺CD27^-)	↓	[13]
DN (IgD^-CD27^-)	↑	[14–16]

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