Figure 6

Immune responses were not altered in KO mice. (A-B) Antigen(NP-CGG)-specific antibody titers [IgM in (A), IgG1 in (B)] in WT and KO mice. Eight mice per group were used for the antigen-injected groups. (C-D) Antigen(TNP-LPS)-specific antibody titers [IgM in (C), IgG3 in (D)]. Between eight and eleven mice per group were used for the antigen-injected groups. (E-F) Antigen(TNP-Ficoll)-specific antibody titers [IgM in (E), IgG3 in (F)]. Between six and eight mice per group were used for the antigen-injected groups. Circles: WT, Triangles: Ziz2KO, Squares: Ziz3 KO, Open symbols: PBS-injected groups, Closed symbols: antigen-injected groups. **: P < 0.01.