The interplay between immune maturation, age, chronic viral infection and environment

Immunity & Ageing

Table 4 T cell activation

Marker	Mean cell numbers ± SEM / μl blood
	SPF-2 Adolescents	Non-SPF Adolescents		Non-SPF Adults
			SPF-2 vs. Non-SPF Adolescents ^a		Non-SPF
			SPF-2 vs. Non-SPF Adolescents ^a		Adolescents vs. Adults ^a
CD4 ⁺ T
CD25	15.89 ± 0.66	13.58 ± 0.45	p = 0.0015	13.88 ± 0.50	NS
CCR5	33.77 ± 2.12	62.92 ± 5.26	p < 0.0001	46.60 ± 3.86	p < 0.0010
CXCR3	ND^b	310.80 ± 20.80		221.30 ± 12.40	p < 0.0001
HLA-DR	15.48 ± 1.29	13.27 ± 1.60	NS^c	7.55 ± 0.54	p < 0.0001
HLA-DR⁺CD25⁺	17.03 ± 5.49	5.00 ± 0.50	p = 0.0180	2.90 ± 0.27	p < 0.0001
CD8 ⁺ T
CD38	388.50 ± 25.54	233.60 ± 25.72	p < 0.0001	107.30 ± 10.39	p < 0.0001
HLA-DR	14.94 ± 1.40	12.55 ± 1.42	NS	9.33 ± 0.76	p = 0.0385
CD38⁺HLA-DR⁺	14.36 ± 1.34	9.12 ± 1.27	p < 0.0100	5.25 ± 0.66	p < 0.0010

^aData between groups were compared by Mann–Whitney analysis. ^bND = not determined; ^c NS = not significant.

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