Table 3 Associations of less functional TLR-1/6/10 genotypes with age

TLR6 (249S/S)

−0.69

0.75

0.001

0.122

−2.17–0.78

−1.20

0.77

0.002

0.355

−2.71–0.32

TLR-1 prom

2.24

1.13

0.004

0.039

0.12–4.56

0.81

1.12

0.001

0.470

−1.39–3.01

TLR-1 (248 S/S)

2.38

1.13

0.004

0.036

0.80–4.05

2.02

1.13

0.004

0.074

0.80–4.05

TLR-1 (602 S/S)

2.68

1.05

0.007

0.014

0.55–4.82

2.57

1.09

0.008

0.015

0.51–4.63

TLR-10 (775 V/V)

−0.39

1.28

0.001

0.760

−2.89–2.11

−0.39

1.33

0.001

0.770

−3.00–2.22

Lithuanian cohort

TLR6 (249S/S)

0.97

0.61

0.002

0.112

−0.23–2.16

−0.97

0.91

0.001

0.288

−2.77–0.83

TLR-1 prom

1.11

0.82

0.001

0.178

−0.51–2.72

3.41

1.15

0.020

0.003

1.15–5.67

TLR-1 (248 S/S)

1.08

0.82

0.001

0.189

−0.53–2.66

3.56

1.17

0.021

0.003

1.26–5.86

TLR-1 (602 S/S)

1.33

0.79

0.003

0.093

−0.22–2.87

2.36

1.10

0.009

0.032

0.20–4.51

TLR-10 (775 V/V)

−1.10

0.96

0.001

0.254

−2.99–0.79

−4.13

1.53

0.016

0.007

−7.12–1.13

Combined

TLR6 (249S/S)

1.88

0.61

0.006

0.002

0.70–3.07

0.74

0.74

0.001

0.310

−0.70–2.19

TLR-1 prom

1.05

0.76

0.001

0.170

−0.45–2.54

2.40

0.85

0.007

0.005

0.74–4.06

TLR-1(248 S/S

1.03

0.76

0.001

0.176

−0.46–2.52

3.24

0.85

0.013

0.001

1.56–4.91

TLR-1 (602 S/S)

1.21

0.73

0.001

0.096

−0.22–2.64

3.24

0.80

0.015

0.032

1.68–4.80

TLR-10 (775 V/V)

0.21

0.87

0.001

0.813

−1.50–1.19

−2.25

1.05

0.004

0.032

−4.30–0.20