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Table 3 Associations of less functional TLR-1/6/10 genotypes with age

From: Less functional variants of TLR-1/-6/-10 genes are associated with age

Predictor German cohort Male Female
  β S.E R2 P 95 % CI β S.E R2 P 95 % CI
TLR6 (249S/S) −0.69 0.75 0.001 0.122 −2.17–0.78 −1.20 0.77 0.002 0.355 −2.71–0.32
TLR-1 prom 2.24 1.13 0.004 0.039 0.12–4.56 0.81 1.12 0.001 0.470 −1.39–3.01
TLR-1 (248 S/S) 2.38 1.13 0.004 0.036 0.80–4.05 2.02 1.13 0.004 0.074 0.80–4.05
TLR-1 (602 S/S) 2.68 1.05 0.007 0.014 0.55–4.82 2.57 1.09 0.008 0.015 0.51–4.63
TLR-10 (775 V/V) −0.39 1.28 0.001 0.760 −2.89–2.11 −0.39 1.33 0.001 0.770 −3.00–2.22
Lithuanian cohort  
TLR6 (249S/S) 0.97 0.61 0.002 0.112 −0.23–2.16 −0.97 0.91 0.001 0.288 −2.77–0.83
TLR-1 prom 1.11 0.82 0.001 0.178 −0.51–2.72 3.41 1.15 0.020 0.003 1.15–5.67
TLR-1 (248 S/S) 1.08 0.82 0.001 0.189 −0.53–2.66 3.56 1.17 0.021 0.003 1.26–5.86
TLR-1 (602 S/S) 1.33 0.79 0.003 0.093 −0.22–2.87 2.36 1.10 0.009 0.032 0.20–4.51
TLR-10 (775 V/V) −1.10 0.96 0.001 0.254 −2.99–0.79 −4.13 1.53 0.016 0.007 −7.12–1.13
Combined  
TLR6 (249S/S) 1.88 0.61 0.006 0.002 0.70–3.07 0.74 0.74 0.001 0.310 −0.70–2.19
TLR-1 prom 1.05 0.76 0.001 0.170 −0.45–2.54 2.40 0.85 0.007 0.005 0.74–4.06
TLR-1(248 S/S 1.03 0.76 0.001 0.176 −0.46–2.52 3.24 0.85 0.013 0.001 1.56–4.91
TLR-1 (602 S/S) 1.21 0.73 0.001 0.096 −0.22–2.64 3.24 0.80 0.015 0.032 1.68–4.80
TLR-10 (775 V/V) 0.21 0.87 0.001 0.813 −1.50–1.19 −2.25 1.05 0.004 0.032 −4.30–0.20
  1. Analysis was carried out by univariate linear regression. Significant P-values below 0.05 were printed in bold