Skip to main content
Fig. 2 | Immunity & Ageing

Fig. 2

From: Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells

Fig. 2

Therapeutic effects of the fetal thymus graft on cellular immunity. To evaluate cellular immunity, the T-cell mitogen (Con A) response was evaluated by MTT assay. Absorbance at 570 nm was determined on a scanning multiwell spectrophotometer. Data are shown at stimulation index (SI), calculated as the ratio of Con A-stimulated to unstimulated T cells. Age-related decline of T-cell functions observed from untreated SAMP1 mice aged 6 months (Group B) to those aged 12 months old (Group C) (*p < 0.05) was recovered in thymus-grafted SAMP1 mice aged 12 months old (Group D, **p < 0.001). There was no significant difference in the Con A responses between untreated SAMP1 aged 2 months old (Group A) and thymus-grafted Group D mice. Experiments were run in triplicate. NS: no significance. n = 3–4/group (mean ± SD)

Back to article page

Immunity & Ageing

ISSN: 1742-4933

Contact us