Skip to main content

Table 1 Demographics of study populations and proportions of lymphocytes

From: Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy

 

YATEC

YAT

YHC

OHC

Number (female/male)

23 (5/18)

12 (7/5)

17 (11/6)

9 (4/5)

CMV (positive/negative)a

10/13

3/8

5/12

5/2

Age (years)b

19.7 ± 8.1 (17.9; 9.0–35.8)

18.4 ± 7.2 (17.4; 9.2–31.3)

23.5 ± 7.9 (25.3; 8.0–33.0)

72.8 ± 4.4 (73.4; 67.0–80.0)

Age at thymectomy (years)b

0.5 ± 0.5 (0.2; 0.01–1.7)

7.6 ± 5.0 (5.1; 2.1–16.8)

n. a.

n. a

Time post thymectomy (years)b

19.7 ± 7.6 (19.7; 8.8–34.2)c

14.4 ± 6.1 (14.6; 3.9–26.1)c

n. a.

n. a.

Lymphocytes absolute/μlb

1.8 ± 0.5 (1.7; 1.3–2.7)

2.1 ± 0.5 (2.1; 1.7–2.5)

2.0 ± 0.4 (2.1; 1.3–2.7)

1.6 ± 0.7 (1.3; 0.9–2.7)

CD3+ (% of lymphocytes)b

70.8 ± 11.9 (75.0; 48.0–85.0)

79.2 ± 2.2 (77.9; 78.0–82.0)

79.0 ± 7.6 (80.9; 62.0–89.0)

69.8 ± 11.8 (70.8; 50.0–85.0)

CD4+ (% of lymphocytes)b

44.6 ± 13.7 (43.0; 35.1–61.4)

51.5 ± 6.8 (48.5; 46.7–59.3)

51.8 ± 6.6 (54.2; 36.5–61.6)

43.2 ± 12.2 (43.6; 28.5–65.9)

CD8+ (% of lymphocytes)b

24.7 ± 7.5 (22.3; 15.4–39.9)

25.7 ± 7.1 (26.3; 16.3–32.4)

25.8 ± 6.9 (26.0; 12.3–38.2)

25.2 ± 8.2 (23.4; 14.3–39.0)

  1. Abbreviations: young adults/adolescents thymectomized in early childhood at ≤24 months of age, YATEC; young adults/adolescents thymectomized in childhood at >24 months of age, YAT; young healthy controls, YHC; old healthy controls, OHC; not applicable, n. a
  2. aCMV serology was unknown in 2 cases of the OHC
  3. bValues are given in mean ± standard deviation (median; range)
  4. cChronological age significantly correlated with time post thymectomy in YATEC (R2–0.958; p = 0.0001) and in YAT (R2 = 0.853; p = 0.0001)