Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration

Table 4 Univariate analysis of C3a, C4a and C5a plasma levels in participants with nAMD with and without subretinal fibrosis

Variables (ng/ml)	Controls (mean ± SD)	Fibrosis absent (mean ± SD)	Fibrosis present (mean ± SD)	P value	P value	P value
Variables (ng/ml)	n = 43	n = 51	n = 45	Fibrosis absent vs present^a	Fibrosis absent vs present vs controls^b	Bonferroni post hoc test
C3a	11.95 ± 3.30	13.68 ± 3.05	15.75 ± 5.51	0.051	<0.001	0.046 ^c
C3a	11.95 ± 3.30	13.68 ± 3.05	15.75 ± 5.51	0.051	<0.001	<0.001 ^d
C4a	68.91 ± 33.23	93.95 ± 59.44	124.94 ± 103.14	0.102	0.004	0.258^c
C4a	68.91 ± 33.23	93.95 ± 59.44	124.94 ± 103.14	0.102	0.004	0.003 ^d
C5a	8.34 ± 2.05	9.14 ± 2.66	9.75 ± 2.80	0.343	0.088

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