TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study

Immunity & Ageing

Table 4 TLR-6 P249S is associated with healthy aging in non-smokers

Disease	Variant	P-value	OR (95 % CI)
All subjects	Variant	P-value	OR (95 % CI)
Combined aging related diseases	P/P	-	-
	P/S	0.281	0.876 (0.689–1.114)
	S/S	0.273	0.825 (0.585–1.163)
	P/S + S/S	0.208	0.864 (0.689–1.085)
Non smokers
Combined aging related diseases	P/P	-	-
	P/S	0.024	0.682 (0.489–0.951)
	S/S	0.018	0.566 (0.353–0.909)
	P/S + S/S	0.008	0.654 (0.477–0.897)

P-values and OR were determined by logistic regression using the wild type genotype as reference, and micro-inflammation (IL-6 level), age and BMI as co-factors. Subjects with a white blood cell count above 10.000/μl were excluded

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