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Table 5 TLR-6 P249S is associated with CVD and DMT 2 in non-smokers

From: TLR-6 SNP P249S is associated with healthy aging in nonsmoking Eastern European Caucasians - A cohort study

Disease Variant P-value OR (95 % CI)
All subjects
CVD P/P - -
P/S 0.188 0.770 (0.522–1.136)
S/S 0.018 0.483 (0.265–0.882)
P/S + S/S 0.061 0.702 (0.484–1.017)
Cancer P/P - -
P/S 0.416 0.745 (0.367–1.513)
S/S 0.353 0.602 (0.207–1.756)
P/S + S/S 0.318 0.710 (0.363–1.390)
Lung disease P/P - -
P/S 0.216 0.732 (0.446–1.201)
S/S 0.509 0.793 (0.399–1.577)
P/S + S/S 0.219 0.746 (0.467–1.191)
DMT 2 P/P - -
P/S 0.007 0.443 (0.244–0.804)
S/S 0.230 0.617 (0.281–1.356)
P/S + S/S 0.010 0.486 (0.281–0.839)
Cognitive impairment P/P - -
P/S 0.284 0.794 (0.522–1.210)
S/S 0.345 0.751 (0.415–1.360)
  P/S + S/S 0.232 0.784 (0.526–1.1168)
Combined aging related diseases, CVD excluded P/P - -
P/S 0.016 0.628 (0.431–0.915)
S/S 0.116 0.656 (0.388–1.109)
P/S + S/S 0.012 0.635 (0.445–0.906)
  1. P-values and OR were determined by logistic regression using the wild type genotype as reference, and micro-inflammation (IL-6 level), age and BMI as co-factors. Subjects with a white blood cell count above 10.000/μl were excluded