Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

Galbavy, William; Lu, Yong; Kaczocha, Martin; Puopolo, Michelino; Liu, Lixin; Rebecchi, Mario J.

doi:10.1186/s12979-017-0091-6

Immunity & Ageing

Table 1 Differential gene expression: largest effect sizes

From: Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

Gene	M/Y	Y Mean	M Mean	Annotation
Abp10	0.46	677	311	Annexin V-binding protein
Aff4	0.45	458	204	Transcription factor and central SEC component
Ago2	0.43	330	141	RISC Catalytic Component 2
Aqp4	0.50	2664	1329	Aquaporin family member
Arl11	2.07	94	195	ADP-ribosylation factor-like 11
Asap1	0.40	524	212	ADP-ribosylation factor (ARF) GTPase-activating protein
Bmpr2	0.46	970	449	Bone morphogenetic protein receptor type II
C3	2.40	830	1996	Central complement component
Chrdl1	2.48	60	148	Ventroptin, antagonizes BMP actions
Clec12a	2.18	99	215	CTL/CTLD member, widely expressed in innate immune system
Cspp1	0.49	207	101	Important for normal neural specific cilia function
Dnajb12	6.70	52	350	DNAJ/HSP40 family member, regulates molecular chaperone activity, protein folding and degradation
Enc1	0.47	135	64	Kelch-related family of actin-binding proteins, role in oxidative stress response, regulates Nrf2
Falz	0.50	482	239	Transcription/epigenetic regulator, up-modulated in neurodegenerative diseases
Fcgr2b	2.89	303	878	Low affinity Fc receptor expressed in microglia
Fcrls	2.78	218	607	Fc receptor; part of TGFb1 microglial signature response
Fmo2	2.35	87	204	Flavin-containing monooxygenase
Fstl3	2.13	66	142	Secreted form binds/antagonizes members of TGF-b family, e.g., BMP2
Gipr	3.49	179	623	Receptor for neuroprotective polypeptide GIP
Golga4	0.42	211	89	Role in Rab6-regulated membrane-tethering events in the Golgi
Gpnmb	3.14	420	1317	Expressed in microglia, inflammatory response gene
Herc1	0.36	294	107	Regulator of membrane trafficking
Kif1a	0.38	3058	1160	Kinesin family protein involved in syaptogenesis
Lgals3	2.44	927	2264	Member galectin family of carbohydrate binding proteins; microglial marker and alt priming gene
Msi2	0.49	304	148	RNA binding protein; role in CNS stem cell proliferation
Nrg1	0.46	553	253	Neuregulin-1, signals through erb2/3 receptors, functions in neural development and plasticity
Pitpnm1	3.50	499	1749	Transfers PtdIns from ER to plasma membrane
Postn	2.73	147	402	Aka periostin; enhances TGF-β signaling, facilitates BMP1, expressed in reactive microglia and astrocytes, neuroprotective
Pou3f1	2.16	266	574	Transcription factor, promotes stem cell commitment to neural fate
RT1-EC2	2.50	75	189	Class I MHC, up-modulated in spinal cord injury and neurodegeneration
S100a8	2.30	85	194	Induced in macrophages and dendritic cells by TLR agonists, oxidative stress and corticosterone
Slc9a3	2.15	195	421	Sodium/proton exchanger; Cation Proton Antiporter 3
Tnc	2.32	75	173	Extracellular matrix protein, up regulated following CNS trauma
Unc5b	0.47	995	469	Netrin receptor family; required for axon guidance; maintains blood–brain barrier
Usp7	0.46	121	56	Uiquitin-specific-processing protease 7, deubiquitinates range Deubiquitinates target proteins

The annotated differential gene set (353) was filtered for largest effect sizes. Mean probe set expression levels (arbitrary units) for Y (young) and M (middle age) genes are shown

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