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Table 1 Differential gene expression: largest effect sizes

From: Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

Gene M/Y Y Mean M Mean Annotation
Abp10 0.46 677 311 Annexin V-binding protein
Aff4 0.45 458 204 Transcription factor and central SEC component
Ago2 0.43 330 141 RISC Catalytic Component 2
Aqp4 0.50 2664 1329 Aquaporin family member
Arl11 2.07 94 195 ADP-ribosylation factor-like 11
Asap1 0.40 524 212 ADP-ribosylation factor (ARF) GTPase-activating protein
Bmpr2 0.46 970 449 Bone morphogenetic protein receptor type II
C3 2.40 830 1996 Central complement component
Chrdl1 2.48 60 148 Ventroptin, antagonizes BMP actions
Clec12a 2.18 99 215 CTL/CTLD member, widely expressed in innate immune system
Cspp1 0.49 207 101 Important for normal neural specific cilia function
Dnajb12 6.70 52 350 DNAJ/HSP40 family member, regulates molecular chaperone activity, protein folding and degradation
Enc1 0.47 135 64 Kelch-related family of actin-binding proteins, role in oxidative stress response, regulates Nrf2
Falz 0.50 482 239 Transcription/epigenetic regulator, up-modulated in neurodegenerative diseases
Fcgr2b 2.89 303 878 Low affinity Fc receptor expressed in microglia
Fcrls 2.78 218 607 Fc receptor; part of TGFb1 microglial signature response
Fmo2 2.35 87 204 Flavin-containing monooxygenase
Fstl3 2.13 66 142 Secreted form binds/antagonizes members of TGF-b family, e.g., BMP2
Gipr 3.49 179 623 Receptor for neuroprotective polypeptide GIP
Golga4 0.42 211 89 Role in Rab6-regulated membrane-tethering events in the Golgi
Gpnmb 3.14 420 1317 Expressed in microglia, inflammatory response gene
Herc1 0.36 294 107 Regulator of membrane trafficking
Kif1a 0.38 3058 1160 Kinesin family protein involved in syaptogenesis
Lgals3 2.44 927 2264 Member galectin family of carbohydrate binding proteins; microglial marker and alt priming gene
Msi2 0.49 304 148 RNA binding protein; role in CNS stem cell proliferation
Nrg1 0.46 553 253 Neuregulin-1, signals through erb2/3 receptors, functions in neural development and plasticity
Pitpnm1 3.50 499 1749 Transfers PtdIns from ER to plasma membrane
Postn 2.73 147 402 Aka periostin; enhances TGF-β signaling, facilitates BMP1, expressed in reactive microglia and astrocytes, neuroprotective
Pou3f1 2.16 266 574 Transcription factor, promotes stem cell commitment to neural fate
RT1-EC2 2.50 75 189 Class I MHC, up-modulated in spinal cord injury and neurodegeneration
S100a8 2.30 85 194 Induced in macrophages and dendritic cells by TLR agonists, oxidative stress and corticosterone
Slc9a3 2.15 195 421 Sodium/proton exchanger; Cation Proton Antiporter 3
Tnc 2.32 75 173 Extracellular matrix protein, up regulated following CNS trauma
Unc5b 0.47 995 469 Netrin receptor family; required for axon guidance; maintains blood–brain barrier
Usp7 0.46 121 56 Uiquitin-specific-processing protease 7, deubiquitinates range Deubiquitinates target proteins
  1. The annotated differential gene set (353) was filtered for largest effect sizes. Mean probe set expression levels (arbitrary units) for Y (young) and M (middle age) genes are shown