Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations

Table 2 Total symptom score and clinical evaluation score (panel A), and rhinomanometry measurements (panel B) of patients with chronic rhinitis, pharyngitis or sinusitis at admission (T0), after nasal inhalations with thermal water (T1) and at phone follow up 1 year later (T2)

A) Total symptom scores in T0 - T1 - T2, and clinical examination scores in T0 – T1
	T0 Mean ± SD (range) N = 183		T1 Mean ± SD (range) N = 165	T2 Mean ± SD (range) N = 74	P - value^a (T0 vs. T1)		P - value^a (T0 vs. T2)
Total symptom score (TSS)	5.7 ± 3.3 (0–18)		2.7 ± 2.3 (0–12)	2.3 ± 2.6 (0–12)	< 0.00001		< 0.00001
Clinical examination score (CES)	1.4 ± 1.2 (0–5)		0.6 ± 0.7 (0–4)	n.a.	< 0.0001		n.a.
B) Rhinomanometry measurements in T0 - T1
	Inhalation resistance (Pa/ml s)				Exhalation resistance (Pa/ml s)
	N	T0 Mean ± SD	T1 Mean ± SD	P - value^b	N	T0 Mean ± SD	T1 Mean ± SD	P - value^b
All patients	105	0.40 ± 0.35	0.51 ± 0.61	NS	103	0.40 ± 0.35	0.53 ± 0.60	=0.01
Pathology^c
J30-J31.0 Rhinitis	28	0.40 ± 0.38	0.63 ± 1.00	NS	28	0.40 ± 0.32	0.67 ± 0.96	NS
J31.1-J31.2 Pharyngitis	24	0.43 ± 0.43	0.44 ± 0.37	NS	24	0.46 ± 0.41	0.45 ± 0.26	NS
J32 Sinusitis	57	0.38 ± 0.28	0.49 ± 0.44	NS	55	0.36 ± 0.31	0.49 ± 0.43	=0.009
Cigarette smoke
Never smokers	47	0.39 ± 0.32	0.44 ± 0.38	NS	49	0.39 ± 0.34	0.46 ± 0.38	NS
Former smokers	46	0.39 ± 0.34	0.53 ± 0.11	NS	41	0.37 ± 0.33	0.60 ± 0.74	NS
Currentsmokers	12	0.52 ± 0.45	0.69 ± 0.84	NS	13	0.48 ± 0.40	0.62 ± 0.81	NS

n.a. not assessed, SD standard deviation, NS not statistically significant (p > 0.05), SD standard deviation
^aWilcoxon signed rank sum test
^bWilcoxon signed rank sum test T0 vs. T1
^cFigures do not add up because 10 patients declared two pathologies simultaneously

ISSN: 1742-4933