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Table. 3 Expression of inflammatory-reparative genes in patients undergoing thermal water nasal inhalation

From: Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations

 

All patients (n = 40)a

J30-J31.0 Rhinitis (n = 10)

J31.1-J31.2 Pharyngitis (n = 7)

J32 Sinusitis (n = 24)

Genes

T0

T1

 

T0

T1

 

T0

T1

 

T0

T1

 
 

Mean ± SD

Mean ± SD

P - valueb

Mean ± SD

Mean ± SD

P - valueb

Mean ± SD

Mean ± SD

P - valueb

Mean ± SD

Mean ± SD

P - valueb

AGER

2.2 ± 2.0

1.9 ± 1.7

NS

2.3 ± 2.4

2.2 ± 2.6

NS

1.5 ± 1.3

1.5 ± 1.0

NS

2.3 ± 2.0

1.9 ± 1.5

NS

CXCR2

1.5 ± 1.3

1.6 ± 1.2

NS

1.2 ± 1.1

1.5 ± 1.2

NS

1.0 ± 1.0

1.1 ± 0.8

NS

1.7 ± 1.4

1.9 ± 1.3

NS

CXCR4

1.4 ± 0.8

4.4 ± 0.7

< 0.0001c

1.4 ± 0.5

4.9 ± 0.9

< 0.0001c

1.4 ± 0.5

4.8 ± 0.5

< 0.0001c

1.4 ± 0.9

4.1 ± 0.6

< 0.0001c

FLT1

1.9 ± 1.4

1.4 ± 0.9

0.005

1.9 ± 0.8

1.7 ± 1.0

NS

1.0 ± 1.0

0.7 ± 0.6

NS

2.2 ± 1.5

1.5 ± 0.9

0.004

FUT7

1.1 ± 1.0

1.3 ± 1.6

NS

1.6 ± 1.4

2.1 ± 1.7

NS

1.1 ± 0.7

1.6 ± 2.6

NS

1.0 ± 0.9

1.0 ± 1.1

NS

HIF1A

3.3 ± 3.3

3.8 ± 2.9

NS

2.2 ± 2.0

2.5 ± 1.9

NS

5.3 ± 4.4

4.6 ± 3.5

NS

3.1 ± 3.1

3.2 ± 2.8

NS

HMGB1

2.3 ± 3.3

2.0 ± 1.9

NS

1.7 ± 1.4

1.6 ± 1.7

NS

1.0 ± 0.9

1.0 ± 0.7

NS

2.8 ± 4.1

2.5 ± 2.1

NS

ICAM1

2.9 ± 2.6

3.1 ± 3.2

NS

2.1 ± 2.0

2.3 ± 1.9

NS

2.5 ± 2.6

2.7 ± 2.7

NS

3.3 ± 2.8

3.6 ± 3.7

NS

NFKB1

4.4 ± 3.4

4.6 ± 3.0

NS

3.5 ± 2.8

3.4 ± 2.9

NS

6.5 ± 3.8

5.2 ± 2.4

NS

4.1 ± 3.4

4.9 ± 3.1

0.04

P2RX7

3.7 ± 3.4

3.4 ± 3.3

NS

2.9 ± 2.9

2.7 ± 2.7

NS

4.0 ± 3.8

3.2 ± 4.3

NS

3.9 ± 3.5

3.7 ± 3.2

NS

PTX3

3.6 ± 4.4

4.1 ± 4.7

NS

4.3 ± 4.1

4.5 ± 4.1

NS

2.8 ± 3.3

2.7 ± 2.6

NS

3.6 ± 4.8

4.3 ± 5.3

NS

RELA

2.7 ± 2.5

2.7 ± 2.0

NS

4.7 ± 3.3

4.2 ± 2.3

NS

1.3 ± 1.2

1.3 ± 1.4

NS

2.4 ± 2.1

2.6 ± 1.7

NS

SELP

2.5 ± 2.4

2.7 ± 2.0

NS

2.8 ± 2.1

3.2 ± 2.2

NS

1.9 ± 1.1

2.0 ± 1.6

NS

2.5 ± 2.8

2.6 ± 2.1

NS

SOCS1

3.0 ± 2.6

2.7 ± 2.2

NS

3.1 ± 2.4

2.6 ± 1.9

NS

4.7 ± 3.2

4.0 ± 2.6

NS

2.5 ± 2.3

2.3 ± 2.1

NS

SOD2

1.7 ± 1.7

2.4 ± 3.2

NS

1.1 ± 0.9

1.1 ± 0.8

NS

1.1 ± 1.0

2.5 ± 2.1

0.007

2.1 ± 2.0

2.9 ± 3.8

NS

TLR2

2.5 ± 2.6

3.1 ± 3.9

NS

2.4 ± 3.5

2.0 ± 3.2

NS

2.7 ± 2.6

3.1 ± 3.2

NS

2.4 ± 2.3

3.5 ± 4.3

NS

TLR3

2.4 ± 2.6

2.4 ± 2.6

NS

2.0 ± 1.7

2.7 ± 2.0

NS

2.9 ± 4.0

2.9 ± 3.9

NS

2.5 ± 2.4

2.1 ± 2.3

NS

TLR4

2.2 ± 1.9

2.6 ± 3.2

NS

2.5 ± 1.4

1.6 ± 1.1

0.02

2.8 ± 3.1

2.7 ± 2.6

NS

1.9 ± 1.5

3.0 ± 3.8

NS

VEGFA

1.5 ± 1.2

2.1 ± 2.7

NS

1.9 ± 1.6

2.0 ± 1.7

NS

1.7 ± 0.9

2.3 ± 1.3

NS

1.3 ± 1.1

2.0 ± 3.2

NS

  1. Numbers indicate fold induction of gene expression relative to the reference genes, such as 18S and GAPDH
  2. NS not statistically significant (p > 0.05), SD standard deviation
  3. aFigures do not add up because one patient declared two pathologies simultaneously
  4. bMann-Whitney U Test p-value
  5. cDifference statistically significant after Bonferroni adjustment for multiple comparisons (76 tests, cut-off is ≈ 0.0007)
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Immunity & Ageing

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