Table 2 Comparisons of immune cell subsets between ESRD and controls

Cell subset percentage

Healthy (57)

ESRD (412)

P value

CD4+ T cells

62.8 (10.3)

56.8 (13.3)↓

0.001*

 Naïve T cells

41.6 (15.6)

28.5 (12.9)↓

< 0.001*

 Stem Memory T cells

3.18 (2.01)

7.50 (6.24)↑

< 0.001*

 Central Memory T cells

30.7 (9.6)

41.6 (11.1)↑

< 0.001*

 Effector Memory T cells

27.0 (14.7)

28.3 (12.9)

0.47

 Terminally Differentiated T cells

1.80 (2.24)

2.36 (2.72)

0.13

CD8+ T cells

26.5 (8.97)

29.2 (10.1)

0.051

 Naïve T cells

32.9 (16.6)

21.8 (16.1)↓

< 0.001*

 Stem Memory T cells

4.78 (5.26)

7.66 (6.20)↑

0.002*

 Central Memory T cells

6.30 (3.58)

7.02 (7.91)

0.50

 Effector Memory T cells

29.1 (11.7)

34.1 (16.6)↑

0.023*

 Terminally Differentiated T cells

32.9 (14.4)

38.1 (16.7)↑

0.025*

 Classical Monocytes

64.1 (12.7)

56.9 (11.7)↓

< 0.001*

 Intermediate Monocytes

6.25 (4.91)

10.1 (6.55)↑

< 0.001*

 Non-Classical Monocytes

14.1 (10.8)

19.9 (9.7)↑

< 0.001*

Absolute cell number

Healthy (57)

ESRD (412)

P value

CD4+ T cells

530 (307)

523 (232)↓

0.02*

 Naïve T cells

247 (199)

164 (112)↓

< 0.001*

 Stem Memory T cells

17.2 (15.5)

11.5 (9.1)↓

< 0.001*

 Central Memory T cells

188 (114)

229 (116)

0.65

 Effector Memory T cells

89.0 (49.5)

120 (86.4)↑

0.006*

 Terminally Differentiated T cells

5.76 (7.59)

9.25 (11.7)

0.10

CD8+ T cells

277 (270)

275 (180)↓

0.012*

 Naïve T cells

103 (97.7)

54.5 (61.9)↓

< 0.001*

 Stem Memory T cells

13.7 (17.6)

4.63 (5.50)↓

< 0.001*

 Central Memory T cells

11.6 (9.22)

12.1 (13.9)

0.47

 Effector Memory T cells

92.9 (58.0)

102 (83.6)

0.26

 Terminally Differentiated T cells

70.2 (53.9)

105 (95.2)↑

0.013*

 Classical Monocytes

248 (91.2)

264 (141)

0.13

 Intermediate Monocytes

19.2 (21.9)

40.3 (33.9)↑

0.001*

 Non-Classical Monocytes

18.4 (12.0)

56.3 (38.2)↑

< 0.001*