Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 2 Comparisons of immune cell subsets between ESRD and controls

From: A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

Cell subset percentage Healthy (57) ESRD (412) P value
CD4+ T cells 62.8 (10.3) 56.8 (13.3)↓ 0.001*
 Naïve T cells 41.6 (15.6) 28.5 (12.9)↓ < 0.001*
 Stem Memory T cells 3.18 (2.01) 7.50 (6.24)↑ < 0.001*
 Central Memory T cells 30.7 (9.6) 41.6 (11.1)↑ < 0.001*
 Effector Memory T cells 27.0 (14.7) 28.3 (12.9) 0.47
 Terminally Differentiated T cells 1.80 (2.24) 2.36 (2.72) 0.13
CD8+ T cells 26.5 (8.97) 29.2 (10.1) 0.051
 Naïve T cells 32.9 (16.6) 21.8 (16.1)↓ < 0.001*
 Stem Memory T cells 4.78 (5.26) 7.66 (6.20)↑ 0.002*
 Central Memory T cells 6.30 (3.58) 7.02 (7.91) 0.50
 Effector Memory T cells 29.1 (11.7) 34.1 (16.6)↑ 0.023*
 Terminally Differentiated T cells 32.9 (14.4) 38.1 (16.7)↑ 0.025*
Monocytes
 Classical Monocytes 64.1 (12.7) 56.9 (11.7)↓ < 0.001*
 Intermediate Monocytes 6.25 (4.91) 10.1 (6.55)↑ < 0.001*
 Non-Classical Monocytes 14.1 (10.8) 19.9 (9.7)↑ < 0.001*
Absolute cell number Healthy (57) ESRD (412) P value
CD4+ T cells 530 (307) 523 (232)↓ 0.02*
 Naïve T cells 247 (199) 164 (112)↓ < 0.001*
 Stem Memory T cells 17.2 (15.5) 11.5 (9.1)↓ < 0.001*
 Central Memory T cells 188 (114) 229 (116) 0.65
 Effector Memory T cells 89.0 (49.5) 120 (86.4)↑ 0.006*
 Terminally Differentiated T cells 5.76 (7.59) 9.25 (11.7) 0.10
CD8+ T cells 277 (270) 275 (180)↓ 0.012*
 Naïve T cells 103 (97.7) 54.5 (61.9)↓ < 0.001*
 Stem Memory T cells 13.7 (17.6) 4.63 (5.50)↓ < 0.001*
 Central Memory T cells 11.6 (9.22) 12.1 (13.9) 0.47
 Effector Memory T cells 92.9 (58.0) 102 (83.6) 0.26
 Terminally Differentiated T cells 70.2 (53.9) 105 (95.2)↑ 0.013*
Monocytes
 Classical Monocytes 248 (91.2) 264 (141) 0.13
 Intermediate Monocytes 19.2 (21.9) 40.3 (33.9)↑ 0.001*
 Non-Classical Monocytes 18.4 (12.0) 56.3 (38.2)↑ < 0.001*
  1. Percentages and absolute numbers (per μl blood) of naïve (TNAIVE), stem cell memory (TSCM), central memory (TCM), effector memory (TEM), terminally differentiated (TEMRA) subsets and three monocyte subsets (classical monocytes, intermediate monocytes, non-classical monocytes) were shown as mean (SD) and were compared between healthy controls and ESRD patients. The inter-group differences were analyzed by Student’s t-test
  2. *P value < 0.05