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Table 3 Independent effects of age and dialysis vintage on immune cell aging

From: A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

Cell Subset (percentage) Age Dialysis Vintage
β P value β P value
CD4+ T cells
 Naïve T cells −0.22 < 0.001* 0.20 0.095
 Stem Memory T cells 0.08 0.029* 0.03 0.72
 Central Memory T cells −0.05 0.24 −0.60 < 0.001*
 Effector Memory T cells 0.26 < 0.001* 0.41 0.001*
 Terminally Differentiated T cells 0.02 0.12 0.02 0.46
CD8+ T cells
 Naïve T cells −0.56 < 0.001* 0.14 0.31
 Stem Memory T cells 0.12 0.002* 0.001 0.91
 Central Memory T cells −0.01 0.61 0.11 0.16
 Effector Memory T cells 0.16 0.014* −0.67 < 0.001*
 Terminally Differentiated T cells 0.42 < 0.001* 0.47 0.002*
Monocytes
 Classical Monocytes 0.02 0.72 −0.32 0.005*
 Intermediate Monocytes −0.03 0.21 0.27 < 0.001*
 Non-Classical Monocytes −0.02 0.64 0.06 0.56
  1. To separate the effects of age from dialysis vintage on immune changes, we tested the independent effects of age and dialysis vintage on cell subset percentages. In a multivariable-adjusted regression model (using subset percentage as the independent variable), the independent associations between immune cell percentage and age as well as the independent associations between immune cell percentage and vintage are shown
  2. *P value < 0.05