A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

Table 4 A combinatorial aging-associated immunophenotype independently associates with coronary artery disease and cardiovascular disease

	OR (95% CI)	P value
Variables in model (independent variable: CAD)
Immunophenotype
High CD8+ T_EMRA High Mon_INT	2.40 (1.18–4.90)	0.016*
High CD8+ T_EMRA Low Mon_INT	1.56 (0.74–3.28)	0.24
Low CD8+ T_EMRA High Mon_INT	1.01 (0.46–2.16)	0.99
Low CD8+ T_EMRA Low Mon_INT	1.00
Age	1.03 (1.01–1.06)	0.003*
Gender (Male)	1.28 (0.79–2.08)	0.31
Diabetes	3.26 (1.99–5.33)	< 0.001*
Albumin (g/dL)	1.21 (0.56–2.21)	0.62
hs-CRP (mg/dL)	1.49 (1.17–1.89)	0.001*
Hemoglobin (g/dL)	1.10 (0.93–1.30)	0.28
Variables in model (independent variable: CVD)
Immunosenescence
High CD8+ T_EMRA High Mon_INT	2.39 (1.21–4.70)	0.012*
High CD8+ T_EMRA Low Mon_INT	1.93 (0.97–3.84)	0.06
Low CD8+ T_EMRA High Mon_INT	1.47 (0.72–2.97)	0.29
Low CD8+ T_EMRA Low Mon_INT	1.00
Age	1.03 (1.01–1.06)	0.001*
Gender (Male)	1.28 (0.81–2.01)	0.29
Diabetes	2.92 (1.86–4.60)	< 0.001*
Albumin (g/dL)	1.03 (0.51–2.08)	0.93
hs-CRP (mg/dL)	1.40 (1.11–1.77)	0.005*
Hemoglobin (g/dL)	1.04 (0.90–1.22)	0.54

Multivariable-adjusted logistic regression models were adjusted for: age, gender, albumin, hemoglobin, DM, hs-CRP and immunophenotype group. The immunophenotype groups were constructed as a categorical variable based on the median-split of the absolute number of CD8+ T_EMRA cells and intermediate monocyte number (Mon_INT), with the Low Mon_INT Low CD8+ T_EMRA group as the reference group. The results were expressed as odds ratio (OR), 95% confidence interval (CI)
*P value < 0.05

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