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Table 4 A combinatorial aging-associated immunophenotype independently associates with coronary artery disease and cardiovascular disease

From: A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

  OR (95% CI) P value
Variables in model (independent variable: CAD)
Immunophenotype
 High CD8+ TEMRA High MonINT 2.40 (1.18–4.90) 0.016*
 High CD8+ TEMRA Low MonINT 1.56 (0.74–3.28) 0.24
 Low CD8+ TEMRA High MonINT 1.01 (0.46–2.16) 0.99
 Low CD8+ TEMRA Low MonINT 1.00  
Age 1.03 (1.01–1.06) 0.003*
Gender (Male) 1.28 (0.79–2.08) 0.31
Diabetes 3.26 (1.99–5.33) < 0.001*
Albumin (g/dL) 1.21 (0.56–2.21) 0.62
hs-CRP (mg/dL) 1.49 (1.17–1.89) 0.001*
Hemoglobin (g/dL) 1.10 (0.93–1.30) 0.28
Variables in model (independent variable: CVD)
Immunosenescence
 High CD8+ TEMRA High MonINT 2.39 (1.21–4.70) 0.012*
 High CD8+ TEMRA Low MonINT 1.93 (0.97–3.84) 0.06
 Low CD8+ TEMRA High MonINT 1.47 (0.72–2.97) 0.29
 Low CD8+ TEMRA Low MonINT 1.00  
Age 1.03 (1.01–1.06) 0.001*
Gender (Male) 1.28 (0.81–2.01) 0.29
Diabetes 2.92 (1.86–4.60) < 0.001*
Albumin (g/dL) 1.03 (0.51–2.08) 0.93
hs-CRP (mg/dL) 1.40 (1.11–1.77) 0.005*
Hemoglobin (g/dL) 1.04 (0.90–1.22) 0.54
  1. Multivariable-adjusted logistic regression models were adjusted for: age, gender, albumin, hemoglobin, DM, hs-CRP and immunophenotype group. The immunophenotype groups were constructed as a categorical variable based on the median-split of the absolute number of CD8+ TEMRA cells and intermediate monocyte number (MonINT), with the Low MonINT Low CD8+ TEMRA group as the reference group. The results were expressed as odds ratio (OR), 95% confidence interval (CI)
  2. *P value < 0.05