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Fig. 5 | Immunity & Ageing

Fig. 5

From: CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2

Fig. 5

Expression of HSP70surface in non-stimulated and stimulated CD56dim and CD56bright cells of the young, old and the oldest Data are presented as means ± SEM and show expression of the studied protein in NK cell subsets demonstrated as the percentage of cells with the expression of a particular protein (%) and mean fluorescence intensity (MFI). The same symbols over bars (#, *, ^) denote statistically significant differences between similarly treated CD56dim or CD56bright cells, i.e. respectively non-stimulated or stimulated by IL-2, LPS or PMA with ionomycin compared between: young vs. old (marked with #), young vs. oldest (marked with *) and old vs. oldest (marked with ^). 3 symbols denote p < 0.001; 2 symbols denote p < 0.01; 1 symbol denotes p < 0.05. Horizontal lines above paired bars denote statistically significant differences between respectively CD56dim or CD56bright cells non-stimulated vs. stimulated by IL-2, LPS or PMA with ionomycin within the same age group. a Expression of HSP70surface in CD56dim cells (%). b Expression of HSP70surface in CD56bright cells (%). c Expression of HSP70surface in CD56dim cells (MFI). d Expression of HSP70surface in CD56bright cells (MFI)

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