Fig. 1

Distribution of IgG in the brain of male and female APOE-TR mice at the age of 3 and 10 months. a Representative images of IgG immunostaining on the brain sections from male APOE3- and APOE4-TR mice at the age of 3 or 10 months. Scale bar: 200 μm. b Representative images of IgG immunostaining on the brain sections from female APOE3- and APOE4-TR mice at the age of 3 or 10 months. Scale bar: 200 μm. c, d Representative images of IgG immunostaining in the hippocampus of male and female APOE-TR mice at the age of 3 or 10 months. Scale bar: 100 μm. e Combination of DAB-staining for IgG (brown) with Nissl staining (blue) in the brain of female APOE-TR mice. Arrows indicated that IgG-positive staining on glia-like cells. Scale bar: 20 μm