Fig. 2

IgG levels in the brain regions of APOE3- and APOE4-TR mice. The total IgG levels in neocortex (a), entorhinal cortex (b), hippocampus (c), thalamus (d), cerebellum (e) and plasma (f) of 3-, 10-month-old male and female APOE3- and APOE4-TR mice. Data were expressed as mean ± SEM and analyzed by ANOVA followed by Bonferroni post-test, Asterisks (*) and pound signs (#) indicate significant difference to APOE3-TR and 3-month-old control mice as indicated, respectively. **P < 0.01, ##P < 0.01, #P < 0.05, n = 4–6