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Table 2 Upstream regulators in ileum identified by Ingenuity pathway analysis based on the comparison between Ercc1-/Δ7 mice receiving A. muciniphila supplementation and control mice

From: Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

Upstream Regulator Activation z-score p-value of overlap
HMGA1 1.66 0.002
POR 1.46 0.000
SYVN1 1.34 0.006
CFTR 1.25 0.000
AR −2.74 0.005
NR1I2 −2.00 0.042
BRCA1 −1.98 0.016
CTNNB1 −1.72 0.001
LEP −1.60 0.031
MAPK14 −1.34 0.020
IL10RA −1.31 0.000
  1. Cut-off values include p < 0.05 and activation z-score < − 1.2 or > 1.2. Upstream regulators in bold are involved in inflammation- and immune-related processes