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Table 2 Upstream regulators in ileum identified by Ingenuity pathway analysis based on the comparison between Ercc1-/Δ7 mice receiving A. muciniphila supplementation and control mice

From: Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

Upstream Regulator

Activation z-score

p-value of overlap

HMGA1

1.66

0.002

POR

1.46

0.000

SYVN1

1.34

0.006

CFTR

1.25

0.000

AR

−2.74

0.005

NR1I2

−2.00

0.042

BRCA1

−1.98

0.016

CTNNB1

−1.72

0.001

LEP

−1.60

0.031

MAPK14

−1.34

0.020

IL10RA

−1.31

0.000

  1. Cut-off values include p < 0.05 and activation z-score < − 1.2 or > 1.2. Upstream regulators in bold are involved in inflammation- and immune-related processes
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Immunity & Ageing

ISSN: 1742-4933

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