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Table 2 Repeated measurements of the cytokine concentrations, overall and by sex, with estimated ICCs

From: Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

Cytokines (pg/ml) First measurement Second measurement P difference* ICC (95% CI)
N Median (IQR) N Median (IQR)
Interleukin-1beta ALL 79 3.12 (0.35–6.50) 82 3.00 (0.39–5.45) 0.89 0.25 (0.02, 0.44)
Men 31 2.71 (0.35–4.42) 30 3.27 (0.23–6.25) 0.72 0.28 (−0.11, 0.57)
Women 48 3.47 (0.44–7.18) 52 2.97 (0.53–5.18) 0.92 0.23 (−0.07, 0.47)
P difference**   0.32   0.77   
Interleukin-2 ALL 143 2.13 (0.21–6.47) 131 1.77 (0.19–5.23) 0.72 0.32 (0.16, 0.46)
Men 59 2.32 (0.21–6.23) 56 2.15 (0.21–4.66) 0.93 0.26 (0.00, 0.48)
Women 84 1.67 (0.20–6.52) 75 0.56 (0.19–6.37) 0.62 0.36 (0.15, 0.54)
P difference   0.82   0.83   
Interleukin-4 ALL 143 2.66 (1.53–5.75) 152 2.75 (1.57–5.98) 0.94 −0.18 (−0.34, −0.02)
Men 56 2.69 (1.52–6.02) 60 2.70 (1.47–5.49) 0.78 −0.23 (−0.47, 0.02)
Women 87 2.63 (1.53–5.61) 92 2.90 (1.65–6.15) 0.64 −0.15 (−0.35, 0.06)
P difference   0.92   0.78   
Interleukin-6 ALL 207 0.52 (0.41–0.79) 207 0.52 (0.40–0.71) 0.06 0.60 (0.51, 0.68)
Men 83 0.59 (0.44–0.82) 83 0.60 (0.44–0.81) 0.55 0.51 (0.34, 0.66)
Women 124 0.50 (0.37–0.76) 124 0.47 (0.38–0.68) 0.04 0.63 (0.51, 0.72)
P difference   0.02   0.001   
Interleukin-8 ALL 207 3.91 (3.10–4.88) 207 3.89 (2.99–5.02) 0.32 0.64 (0.55, 0.71)
Men 83 3.96 (3.19–4.96) 83 4.19 (3.20–5.62) 0.07 0.62 (0.47, 0.74)
Women 124 3.67 (3.03–4.73) 124 3.62 (2.81–4.74) 0.81 0.63 (0.51, 0.73)
P difference   0.14   0.004   
Interleukin-10 ALL 207 0.25 (0.18–0.34) 207 0.25 (0.18–0.34) 0.76 0.58 (0.48, 0.66)
Men 83 0.28 (0.19–0.36) 83 0.26 (0.19–0.35) 0.03 0.38 (0.18, 0.55)
Women 124 0.24 (0.17–0.31) 124 0.24 (0.18–0.33) 0.13 0.72 (0.63, 0.80)
P difference   0.02   0.35   
Interleukin-12p70 ALL 194 0.30 (0.15–6.01) 203 0.31 (0.16–6.01) 0.98 0.35 (0.22, 0.47)
Men 78 1.90 (0.13–6.69) 81 1.06 (0.14–6.00) 0.29 0.27 (0.05, 0.46)
Women 116 0.22 (0.15–5.32) 122 0.27 (0.16–6.20) 0.30 0.40 (0.24, 0.54)
P difference   0.31   0.87   
Interleukin-13 ALL 167 0.67 (0.43–0.92) 168 0.77 (0.52–1.04) 0.01 0.43 (0.30, 0.55)
Men 69 0.55 (0.41–0.76) 67 0.63 (0.44–0.97) 0.12 0.43 (0.21, 0.60)
Women 98 0.75 (0.49–0.20) 101 0.83 (0.61–1.08) 0.06 0.39 (0.21, 0.54)
P difference   0.01   0.01   
Interferon-gamma ALL 207 3.06 (2.12–4.61) 207 3.06 (2.18–4.21) 0.43 0.40 (0.28, 0.51)
Men 83 2.81 (2.09–4.29) 83 2.82 (2.06–3.87) 0.66 0.28 (0.07, 0.46)
Women 124 3.37 (2.16–4.86) 124 3.26 (2.22–4.44) 0.46 0.48 (0.33, 0.61)
P difference   0.28   0.14   
Tumor Necrosis Factor alpha ALL 207 1.94 (1.56–2.39) 207 1.96 (1.57–2.40) 0.07 0.70 (0.63, 0.77)
Men 83 2.04 (1.64–2.40) 83 2.14 (1.60–2.50) 0.44 0.77 (0.66, 0.84)
Women 124 1.87 (1.51–2.36) 124 1.87 (1.56–2.33) 0.10 0.65 (0.53, 0.74)
P difference   0.07   0.08   
  1. *P value for difference based on Wilcoxon signed rank test between first and second measurements. **P value for difference based on Wilcoxon rank sum test between men and women (Kruskal Wallis) Abbreviations: ICC Intraclass correlation coefficient, IQR Interquartile range, CI Confidence interval