Fig. 1

B cells and B cell subpopulations in peripheral blood upon aging. a. WBC counts. b-c. Analysis of total cell numbers (b) and relative frequencies (c) of B cells. d-n. Total numbers of different B cell subpopulations (d-m), and relative distribution of B cell subpopulations (n). Data were evaluated for four age categories: < 50 (n = 47), 50–60 (n = 31), 60–70 (n = 45), and > 70 (n = 32). Statistical significance between age groups was determined using the Mann-Whitney U test; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001