Fig. 3
![Fig. 3](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12979-019-0163-x/MediaObjects/12979_2019_163_Fig3_HTML.png)
BCR repertoire analysis in naive mature B cells upon aging. a. Comparison of HCDR3 lengths in < 50, 50–70, and 70 + y age categories. Statistical significance was determined using the Kolmogorov-Smirnov test. b. Circos plots of the combination of IGHV-IGHJ gene usage in < 50, 50–70, and 70 + y age categories. c. Differences in IGHV gene usage frequencies upon aging. Statistical significance between different age groups was determined using the two-way ANOVA test (with Bonferroni multiple comparisons correction); *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001