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Fig. 2 | Immunity & Ageing

Fig. 2

From: Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge

Fig. 2

Survival after A/California/07/2009 H1N1 challenge. Aged BALB/c female mice (18–22 months of age) were immunized twice with H1-VLP vaccine or inactivated split vaccine. Six weeks after vaccination, mice were challenged with a sub-lethal dose of A/California/07/2009 H1N1 and were closely monitored for weight loss. Mice were euthanized if they lost > 20% of their initial weight A log-rank (Mantel-Cox) test was used to compare survival curves with the PBS control group (** p < 0.01, * p < 0.05). This graph is representative of 5–10 mice/group from two separate studies

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