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Table 3 Bone parameters (fracture, BMD and TBS) according to quartiles of interleukin 1β

From: “Inflammaging” and bone in the OsteoLaus cohort

 FirstSecondThirdFourthP-valueaP-value trend testbP-value adjustedc
N381279329329   
Interleukin 1β, median [IQR]undetectables0.32 [0.25–0.43]1.13 [0.84–1.50]5.86 [3.02–12.8]   
Traumatic fracture (%)98 (25.7)87 (31.1)85 (25.8)75 (22.8)0.131 0.275
Major osteoporotic fracture (%)54 (14.1)27 (9.68)30 (9.1)31 (9.4)0.090 0.176
Incident fracture 5 years25/374 (6.6)18/272 (6.6)12/318 (3.7)20/320 (6.2)0.341 0.368
Spine average BMD0.918 ± 0.1630.937 ± 0.1750.940 ± 0.1570.910 ± 0.1610.0570.6260.606
Spine average T-score−1.16 ± 1.55−1.00 ± 1.62−0.94 ± 1.47− 1.21 ± 1.520.070.7730.801
Spine average TBS1.318 ± 0.1081.323 ± 0.1081.329 ± 0.0981.316 ± 0.0950.3390.9410.329
Femoral neck BMD0.724 ± 0.1100.740 ± 0.1250.732 ± 0.1090.725 ± 0.1150.2570.9030.683
Femoral neck T-score−1.12 ± 0.99−0.98 ± 1.12−1.05 ± 0.98− 1.11 ± 1.030.2890.9470.721
Femur total BMD0.848 ± 0.1180.860 ± 0.1260.862 ± 0.1160.851 ± 0.1120.3330.6640.918
Femur total T-score−0.77 ± 0.96− 0.67 ± 1.03−0.65 ± 0.94− 0.74 ± 0.910.3420.7350.998
  1. Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variablesa, p of trendb and after multiple adjustmentc (age, BMI, smoker, diabetes, alcohol, calcium, HRT)