“Inflammaging” and bone in the OsteoLaus cohort

Immunity & Ageing

Table 3 Bone parameters (fracture, BMD and TBS) according to quartiles of interleukin 1β

	First	Second	Third	Fourth	P-value^a	P-value trend test^b	P-value adjusted^c
N	381	279	329	329
Interleukin 1β, median [IQR]	undetectables	0.32 [0.25–0.43]	1.13 [0.84–1.50]	5.86 [3.02–12.8]
Traumatic fracture (%)	98 (25.7)	87 (31.1)	85 (25.8)	75 (22.8)	0.131		0.275
Major osteoporotic fracture (%)	54 (14.1)	27 (9.68)	30 (9.1)	31 (9.4)	0.090		0.176
Incident fracture 5 years	25/374 (6.6)	18/272 (6.6)	12/318 (3.7)	20/320 (6.2)	0.341		0.368
Spine average BMD	0.918 ± 0.163	0.937 ± 0.175	0.940 ± 0.157	0.910 ± 0.161	0.057	0.626	0.606
Spine average T-score	−1.16 ± 1.55	−1.00 ± 1.62	−0.94 ± 1.47	− 1.21 ± 1.52	0.07	0.773	0.801
Spine average TBS	1.318 ± 0.108	1.323 ± 0.108	1.329 ± 0.098	1.316 ± 0.095	0.339	0.941	0.329
Femoral neck BMD	0.724 ± 0.110	0.740 ± 0.125	0.732 ± 0.109	0.725 ± 0.115	0.257	0.903	0.683
Femoral neck T-score	−1.12 ± 0.99	−0.98 ± 1.12	−1.05 ± 0.98	− 1.11 ± 1.03	0.289	0.947	0.721
Femur total BMD	0.848 ± 0.118	0.860 ± 0.126	0.862 ± 0.116	0.851 ± 0.112	0.333	0.664	0.918
Femur total T-score	−0.77 ± 0.96	− 0.67 ± 1.03	−0.65 ± 0.94	− 0.74 ± 0.91	0.342	0.735	0.998

Results are expressed as number of participants (%) or as mean ± standard deviation. Statistical analysis performed using chi-square for categorical variables and ANOVA for continuous variables^a, p of trend^b and after multiple adjustment^c (age, BMI, smoker, diabetes, alcohol, calcium, HRT)

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