Fig. 2

Kinetics of HBsAb titers for IM Seniors by gender and IgG subclass responses. a. Percent of individuals with titers above seroprotection threshold and b. Individual and geometric mean titers (horizontal lines) for men (shaded diamonds) and women (open circles) over time. The solid line indicates the threshold for protective response (10 IU/L). Significant differences by WMW test of AUCs: p = 0.084 Female vs. Male Senior GMTs. c and d. HBsAb IgG isotype profile in Juniors (n = 9) and Seniors (n = 16 days 0, 30, 60; n = 17 days 210, 360). Data represent GMT, with 95% CI indicated by error bars. Significant differences by WMW test of AUCs: p = 0.0019 IgG2 vs IgG1; p < 0.0001 IgG2 vs IgG3; p < 0.0001 IgG2 vs IgG4. IgG1 responses in Seniors were significantly lower than Juniors (p = 0.0007 by WMW test of AUCs)