Table 2 Immune cell number and phenotype comparisons by CKD stage
From: Emergence of T cell immunosenescence in diabetic chronic kidney disease
|  | eGFR ≥60 (n = 379) | Stage 3 CKD (n = 110) | Stage 4/5 CKD (n = 34) | p value |
|---|---|---|---|---|
Number CD3+ | 1023.2 (418.1) | 964.8 (447.5) | 788.0 (311.2) | 0.005* |
Number CD4+ | 604.4 (277.0) | 555.3 (248.7) | 450.1 (200.7) | 0.003* |
Number CD8+ | 282.8 (158.6) | 293.1 (190.4) | 221.4 (134.0) | 0.079 |
CD4+ TNAIVE (%) | 37.7 (14.1) | 38.6 (15.6) | 39.1 (16.7) | 0.78 |
CD4+ TEFF (%) | 3.2 (3.9) | 3.3 (3.8) | 4.7 (4.8) | 0.093 |
CD4+ CD127+ (%) | 92.4 (5.3) | 90.7 (6.9) | 88.4 (7.1) | < 0.001* |
CD4+ CD28- (%) | 7.1 (8.3) | 9.0 (9.1) | 7.9 (6.3) | 0.12 |
CD4+ CD57+ (%) | 4.2 (4.8) | 5.3 (5.9) | 5.1 (5.6) | 0.096 |
CD8+ TNAIVE (%) | 22.9 (12.5) | 19.9 (12.3) | 18.5 (10.4) | 0.02* |
CD8+ TEFF (%) | 31.5 (17.5) | 38.8 (19.4) | 38.9 (19.6) | < 0.001* |
CD8+ CD127+ (%) | 55.1 (16.3) | 46.9 (16.6) | 47.8 (14.5) | < 0.001* |
CD8+ CD28- (%) | 45.2 (17.7) | 54.8 (17.2) | 53.8 (18.2) | < 0.001* |
CD8+ CD57+ (%) | 27.3 (17.4) | 33.1 (20.5) | 33.7 (18.0) | 0.003* |
Number CD68+ | 378.0 (146.7) | 412.0 (162.8) | 383.2 (159.4) | 0.12 |
Monocyte 1 (%) | 75.2 (8.9) | 75.3 (9.9) | 76.5 (9.1) | 0.74 |
Monocyte 2 (%) | 3.7 (1.7) | 3.8 (2.4) | 3.7 (1.9) | 0.76 |
Monocyte 3 (%) | 10.7 (4.7) | 10.8 (7.0) | 10.2 (5.7) | 0.85 |