Fig. 4
From: Autoimmune hemolytic anemia: current knowledge and perspectives
Hemolysis in CAD, adapted and modified from Berentsen et al. [72, 74]. Activation of the complement cascade caused by the reaction of cold agglutinins with RBCs leads to intravascular and extravascular hemolysis. Extravascular hemolysis is associated with complement activation and destruction of RBCs by the mononuclear phagocytic system, mainly in the liver. Intravascular hemolysis is a result of the formation of membrane attack complex (MAC), composed of C5b, C6, C7, C8, and C9