Fig. 2
Age-dependent association of CD4+ and CD8+ TRM frequencies and T cell subsets in terminal ileum mucosa following oral Ty21a immunization. Correlations between age and the frequencies of tissue resident T cells were determined using Pearson’s analysis. a Unvaccinated LPMC CD4+ CD103+ TRM (black symbols), and CD4+ CD103- TRM (blue symbols), as well as Ty21a-vaccinated LPMC CD4+ CD103+ TRM (green symbols) and CD4+ CD103- TRM (red symbols) frequencies were correlated to the age of the volunteers. b Similarly, unvaccinated LPMC CD8+ TRM cells (black symbols), and CD8+ CD103- T cells (blue symbols), and Ty21a-vaccinated LPMC CD8+ TRM (green symbols) and CD8+ CD103- T cells (red symbols) frequencies were correlated to the age of the volunteers. Significant correlations are denoted with * P < 0.05. Trends to exhibit significant correlations are indicated by their p-values