Fig. 6
LPMC multifunctional (MF) and single-expressing (S) S. Typhi–specific CD8+ TEM responses in adults compared to elderly volunteers following Ty21a immunization. Net S. Typhi-specific CD8+ TEM responses were calculated using the FCOM function of Winlist and stratified into S and MF responses. Comparison of TI LPMC S. Typhi-specific CD8+ TEM responses in (a) CD107a+, (b) INF-γ, (c) TNF-α+, (d) IL-17A+, (e) IL-2+, and (f) MIP-1β + S and MF between adults (A- < 60 yrs.) and elderly (E- ≥ 60 yrs.) volunteers that were either orally vaccinated with Ty21a (red symbols) or unvaccinated (black symbols). Trends to exhibit significant values are indicated by their p-values. Horizontal black bars represent median values