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Fig. 5 | Immunity & Ageing

Fig. 5

From: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

Fig. 5

Cytokine secretion profile of CD4+ and CD8+ T cells is altered according to age in spleen of SPF mice. a and c Contour plots showing the cytokine gates for CD4+ (a) and CD8+ T cells (c) in unstimulated and 5 hours, phorbol-myristate-acetate and ionomycin stimulated samples from a representative old SPF mouse spleen sample. b and d Summary of the frequencies of cytokine-positive cells in CD4+ (b) and CD8+ T cells (d) *P < 0.05, **P < 0.01, ***P < 0.001 Mann-Whitney test. NS indicates non-significant changes. (Young n = 6 and old n = 13)

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Immunity & Ageing

ISSN: 1742-4933

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