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Table 5 Diagnostic validity of laboratory parameters

From: The age again in the eye of the COVID-19 storm: evidence-based decision making

   AUCa AUC 95% ICb LR + c LR-d YIe Sensitivity (%) Specificity (%)
IL6f (pg/mL)
 Best cut-off 69.08 0.70 0.64–0.76    0.31 51.24 79.86
 Best cut-off for LR+ 175.1    5.2    28.10 94.60
 Best cut-off for LR- 5.56     0.19   97.52 12.59
CRPg (mg/L)
 Best cut-off 97.3 0.67 0.65–0.73    0.28 62.18 66.05
 Best cut-off for LR+ 291.85    5.16    14.29 97.23
 Best cut-off for LR- 7     0.21   97.90 11.62
Ferritin (ng/mL)
 Best cut-off 632.5 0.67 0.62–0.73    0.29 72.66 56.79
 Best cut-off for LR+ 2688.5    5.51    12.23 87.77
 Best cut-off for LR- 162     0.17   97.12 16.62
LDHh (U/L)
 Best cut-off 328.5 0.71 0.66–0.75    0.36 65.58 70.62
 Best cut-off for LR+ 574    5.34    17.21 96.78
 Best cut-off for LR- 177.5     0.3   88.37 30.99
D-dimer (ng/mL)
 Best cut-off 1068 0.62 0.57–0.66    0.21 45.28 76.12
 Best cut-off for LR+ 34,744    4.62    1.89 99.59
 Best cut-off for LR- None       na. na.
Leucocyte count (cells*103/μL)
 Best cut-off 7.835 0.62 0.58–0.67    0.22 50.57 71.90
 Best cut-off for LR+ 15.875    5.14    9.89 98.08
 Best cut-off for LR- None       na. na.
Neutrophil count (cells*103/μL)
 Best cut-off 6.26 0.66 0.62–0.70    0.27 51.33 75.44
 Best cut-off for LR+ 13.04    5.37    12.17 97.74
 Best cut-off for LR- None       na. na.
Lymphocyte count (cells*103/μL)
 Best cut-off 0.725 0.61 0.57–0.65    0.18 39.92 77.66
 Best cut-off for LR+ 0.365    5.34    10.27 98.08
 Best cut-off for LR- None       na. na.
CD3 + CD4+ count (cells/μL)        
 Best cut-off 535.5 0.70 0.61–0.80    0.41 90.32 50.51
 Best cut-off for LR+ 95.74    4.79    9.68 97.98
 Best cut-off for LR- 660.6     0.16   93.55 39.39
CD4 + CD8+ count (cells/μL)
 Best cut-off 162.83 0.63 0.52–0.75    0.22 58.06 63.64
 Best cut-off for LR+ None       na. na.
 Best cut-off for LR- None       na. na.
CD19+ count (cells/μL)
 Best cut-off na.i 0.59 0.47–0.71    na. na. na.
 Best cut-off for LR+ na.       na. na.
 Best cut-off for LR- na.       na. na.
Natural Killer count (cells/μL)
 Best cut-off 147.5 0.65 0.54–0.77    0.28 75.00 53.26
 Best cut-off for LR+ 43.29    5.11    16.67 96.74
 Best cut-off for LR- 229.38     0.18   95.83 22.83
  1. Abbreviations: AUCa Area under the curve, AUC 96% ICb 95% Confidence Intervale of the area under the curve, LRc Likelyhood ratio positive, LR-d Likelyhood ratio negative, YIe Youden Index, IL6f Interleukin 6, CRPg C-reactive protein, LDHh Lactate dehydrogenase, na.i Non aplicable