The age again in the eye of the COVID-19 storm: evidence-based decision making

Martín, María C.; Jurado, Aurora; Abad-Molina, Cristina; Orduña, Antonio; Yarce, Oscar; Navas, Ana M.; Cunill, Vanesa; Escobar, Danilo; Boix, Francisco; Burillo-Sanz, Sergio; Vegas-Sánchez, María C.; Jiménez-de las Pozas, Yesenia; Melero, Josefa; Aguilar, Marta; Sobieschi, Oana Irina; López-Hoyos, Marcos; Ocejo-Vinyals, Gonzalo; San Segundo, David; Almeida, Delia; Medina, Silvia; Fernández, Luis; Vergara, Esther; Quirant, Bibiana; Martínez-Cáceres, Eva; Boiges, Marc; Alonso, Marta; Esparcia-Pinedo, Laura; López-Sanz, Celia; Muñoz-Vico, Javier; López-Palmero, Serafín; Trujillo, Antonio; Álvarez, Paula; Prada, Álvaro; Monzón, David; Ontañón, Jesús; Marco, Francisco M.; Mora, Sergio; Rojo, Ricardo; González-Martínez, Gema; Martínez-Saavedra, María T.; Gil-Herrera, Juana; Cantenys-Molina, Sergi; Hernández, Manuel; Perurena-Prieto, Janire; Rodríguez-Bayona, Beatriz; Martínez, Alba; Ocaña, Esther; Molina, Juan

doi:10.1186/s12979-021-00237-w

Immunity & Ageing

Table 5 Diagnostic validity of laboratory parameters

From: The age again in the eye of the COVID-19 storm: evidence-based decision making

		AUC^a	AUC 95% IC^b	LR + ^c	LR-^d	YI^e	Sensitivity (%)	Specificity (%)
IL6^f (pg/mL)
Best cut-off	69.08	0.70	0.64–0.76			0.31	51.24	79.86
Best cut-off for LR+	175.1			5.2			28.10	94.60
Best cut-off for LR-	5.56				0.19		97.52	12.59
CRP^g (mg/L)
Best cut-off	97.3	0.67	0.65–0.73			0.28	62.18	66.05
Best cut-off for LR+	291.85			5.16			14.29	97.23
Best cut-off for LR-	7				0.21		97.90	11.62
Ferritin (ng/mL)
Best cut-off	632.5	0.67	0.62–0.73			0.29	72.66	56.79
Best cut-off for LR+	2688.5			5.51			12.23	87.77
Best cut-off for LR-	162				0.17		97.12	16.62
LDH^h (U/L)
Best cut-off	328.5	0.71	0.66–0.75			0.36	65.58	70.62
Best cut-off for LR+	574			5.34			17.21	96.78
Best cut-off for LR-	177.5				0.3		88.37	30.99
D-dimer (ng/mL)
Best cut-off	1068	0.62	0.57–0.66			0.21	45.28	76.12
Best cut-off for LR+	34,744			4.62			1.89	99.59
Best cut-off for LR-	None						na.	na.
*Leucocyte count (cells10³/μL)**
Best cut-off	7.835	0.62	0.58–0.67			0.22	50.57	71.90
Best cut-off for LR+	15.875			5.14			9.89	98.08
Best cut-off for LR-	None						na.	na.
*Neutrophil count (cells10³/μL)**
Best cut-off	6.26	0.66	0.62–0.70			0.27	51.33	75.44
Best cut-off for LR+	13.04			5.37			12.17	97.74
Best cut-off for LR-	None						na.	na.
*Lymphocyte count (cells10³/μL)**
Best cut-off	0.725	0.61	0.57–0.65			0.18	39.92	77.66
Best cut-off for LR+	0.365			5.34			10.27	98.08
Best cut-off for LR-	None						na.	na.
CD3 + CD4+ count (cells/μL)
Best cut-off	535.5	0.70	0.61–0.80			0.41	90.32	50.51
Best cut-off for LR+	95.74			4.79			9.68	97.98
Best cut-off for LR-	660.6				0.16		93.55	39.39
CD4 + CD8+ count (cells/μL)
Best cut-off	162.83	0.63	0.52–0.75			0.22	58.06	63.64
Best cut-off for LR+	None						na.	na.
Best cut-off for LR-	None						na.	na.
CD19+ count (cells/μL)
Best cut-off	na.ⁱ	0.59	0.47–0.71			na.	na.	na.
Best cut-off for LR+	na.						na.	na.
Best cut-off for LR-	na.						na.	na.
Natural Killer count (cells/μL)
Best cut-off	147.5	0.65	0.54–0.77			0.28	75.00	53.26
Best cut-off for LR+	43.29			5.11			16.67	96.74
Best cut-off for LR-	229.38				0.18		95.83	22.83

Abbreviations: AUC^a Area under the curve, AUC 96% IC^b 95% Confidence Intervale of the area under the curve, LR^c Likelyhood ratio positive, LR-^d Likelyhood ratio negative, YI^e Youden Index, IL6^f Interleukin 6, CRP^g C-reactive protein, LDH^h Lactate dehydrogenase, na.ⁱ Non aplicable

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