Table 3 Frequency of B cell subsets in the healthy controls and kidney transplant patients pre- and post-transplantation
pre-Tx (N = 36) | post-Tx (N = 36) | HC (N = 27) | p value | |||
|---|---|---|---|---|---|---|
pre-Tx vs post-Tx | HC vs pre-Tx | HC vs post-Tx | ||||
CD19+/Lymphocytes (%) | 6.2 (3.6–9.5) | 2.9 (2.0–4.7) | 5.9 (4.7–8.6) | < 0.001 | ns | < 0.001 |
Naive B cells/CD19+ (%) | 64.4 (51.8–73.2) | 61.9 (44.5–71.5) | 63.9 (52.5–68.5) | 0.032 | ns | ns |
Transitional B cells/CD19+ (%) | 2.0 (0.3–3.5) | 0.7 (0.4–2.1) | 1.2 (0.5–3.3) | 0.020 | ns | ns |
PB/PC B cells /CD19+ (%) | 0.4 (0.3–1.3) | 0.5 (0.2–0.9) | 0.6 (0.4–1.1) | ns | ns | ns |
Memory B cells /CD19+ (%) | 26.7 (20.2–44.6) | 33.4 (26.6–51.6) | 32.3 (24.9–43.2) | 0.011 | ns | ns |
Switched Memory B cells /Memory B cells (%) | 50.6 (40.6–57.6) | 47.3 (36.6–58.2) | 38.5 (32.7–43.5) | ns | < 0.001 | 0.004 |
Non-Switched Memory B cells/Memory B cells (%) | 38.5 (26.2–47.7) | 39.9 (26.2–51.7) | 52.2 (45.9–56.0) | ns | < 0.001 | < 0.001 |
IgM Only Memory B cells/Memory B cells (%) | 2.6 (1.7–4.6) | 2.3 (1.6–3.8) | 2.6 (1.5–4.0) | ns | ns | ns |
ABCs/CD19+ (%) | 5.3 (3.5–8.1) | 8.0 (5.3–11.0) | 6.0 (5.3–7.2) | 0.003 | ns | ns |