Table 3 Subgroup analysis on the relationship between the combined effects of high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c) with the risk of dementia, Alzheimer’s disease, and vascular dementia
Combined effect of hs-CRP and HbA1c | Numbers | Incidence rate per 10,000 PYs | Adjusted model †| |
|---|---|---|---|---|
| Â | HR (95% CI) | P-value * | ||
Primary endpoints of dementia among those without diabetes mellitus (n = 3838) | ||||
 High levels of both hs-CRP and HbA1c | 741 | 42.87 | 2.17 (0.98 ~ 4.77) | 0.055 |
 High level of only hs-CRP | 569 | 33.26 | 2.89 (1.27 ~ 6.56) | 0.011 |
 High level of only HbA1c | 898 | 50.12 | 2.27 (1.11 ~ 4.67) | 0.026 |
 Non-high levels in both | 1630 | 7.48 | 1.00 |  |
Primary endpoints of dementia among those aged less than 65 years # (n = 3481) | ||||
 High levels of both hs-CRP and HbA1c | 667 | 3.70 | 5.75 (0.39 ~ 85.70) | 0.205 |
 High level of only hs-CRP | 531 | 6.97 | 11.33 (1.05 ~ 122.39) | 0.046 |
 High level of only HbA1c | 772 | 6.34 | 5.03 (0.50 ~ 51.09) | 0.172 |
 Non-high levels in both | 1511 | 0.80 | 1.00 |  |
Primary endpoints of dementia among those aged 65 years and older & (n = 632) | ||||
 High levels of both hs-CRP and HbA1c | 105 | 172.71 | 1.21 (0.59 ~ 2.50) | 0.599 |
 High level of only hs-CRP | 113 | 274.49 | 1.33 (0.77 ~ 2.31) | 0.307 |
 High level of only HbA1c | 120 | 257.37 | 1.75 (0.97 ~ 3.16) | 0.064 |
 Non-high levels in both | 294 | 194.98 | 1.00 |  |
Secondary endpoints of Alzheimer’s disease among the total sample ‡ (n = 4113) | ||||
 High levels of both hs-CRP and HbA1c | 756 | 11.83 | 5.3 (0.94 ~ 29.85) | 0.059 |
 High level of only hs-CRP | 682 | 0.00 | – | – |
 High level of only HbA1c | 772 | 9.68 | 3.24 (0.58 ~ 18.03) | 0.179 |
 Non-high levels in both | 1903 | 1.28 | 1.00 |  |
Secondary endpoints of vascular dementia among the total sample ‡ (n = 4113) | ||||
 High levels of both hs-CRP and HbA1c | 756 | 15.22 | 4.92 (0.97 ~ 24.87) | 0.054 |
 High level of only hs-CRP | 682 | 5.49 | 2.89 (0.47 ~ 17.85) | 0.254 |
 High level of only HbA1c | 772 | 14.55 | 4.17 (0.87 ~ 19.94) | 0.074 |
 Non-high levels in both | 1903 | 1.28 | 1.00 |  |