Fig. 1

Effect of subsets of CMV-responsive T cells that significantly predicted onset of frailty. Shown are Kaplan-Meier survival curves (unadjusted) depicting onset of frailty among HIV- and HIV+ men, stratified by tertiles (1 = lowest, 3 = highest) of percentages of IFN-γ-SP CD4 T cells (a-d) and of IFN-γ-, TNF-α-, and IL-2- (triple)-producing CD8 T cells(e-h). The left column compares men in the lowest tertile of these percentages to those in the upper two tertiles; the right column compares men in the lower two tertiles to those in the top tertile among HIV- (a, b and e, f) and HIV+ (c, d and g, h) men. The number at risk indicates the number of people who were at risk of onset of frailty at the beginning of each time point. The P-values shown were obtained from the exact log-rank test; values in red indicate statistical significance. Hash marks and the numbers on survival curves indicate censoring times and the numbers of individuals censored at a given time point, respectively