Fig. 2

Prediction of frailty in HIV- nonfrail men by combinations of two subsets of CMV-specific cytokine-producing T cells. Kaplan-Meier survival curves (unadjusted) show the onset of frailty stratified by tertiles (1 = lowest, 3 = highest) of percentages of IFN-γ-SP CD4 T cells and TP CD8 T cells among HIV- nonfrail men (a) and among HIV+ nonfrail men (b), and by tertiles of IFN-γ-SP CD4 T cells and total IL-2-producing CD4 T cells among HIV- nonfrail men (c). In (a), HIV- nonfrail men were divided into three groups: those in both the highest tertile of IFN-γ-SP CD4 T cells and the lowest tertile of triple cytokine-producing CD8 T cells (blue line); those in either the highest tertile of IFN-γ-SP CD4 T cells or the lowest tertile of TP CD8 T cells, but not both (red line); and all other HIV- nonfrail men (green line). In (b), HIV+ nonfrail men were divided into those in the lowest tertile of both cell subsets (blue line), those in the lowest tertiles of either cell subset, but not. Both (red line), and those in the higher 2 tertiles of both cell subsets (green line). In (c), HIV- nonfrail men were divided into those in the highest tertile of both IFN-γ-SP CD4 T cells and total IL-2-producing CD4 T cells (blue line), those in the highest tertiles of either cell subset (red line), and those in the lower 2 tertiles of both cell subsets (green line). P-values shown in a-c were obtained by Fisher’s exact test. Numbers at risk, hash markers, and numbers on the survival curves are as described in legend of Fig. 1