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Fig. 7 | Immunity & Ageing

Fig. 7

From: Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches

Fig. 7

Microglia promotes T cell infiltration in the aged CNS. Microglia shift towards a pro-inflammatory state in the aged CNS and promote CD8+ memory T cell recruitment by releasing CCL3. Aged microglia release TNF-α, which upregulates the expression of VCAM1 and ICAM1 in venous BECs. The activated venous BECs adhere tightly to hematogenous CD8+ memory T cells and promote their transmigration into the CNS. The infiltrated T cells interact with brain resident cells by releasing CCL4, CCL5, IFN-γ, XCL1, FASLG

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Immunity & Ageing

ISSN: 1742-4933

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