Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Immunity & Ageing

Table 1 The hormesis activity of natural compounds in vivo in adaptive responses of mitochondria

Activity	Compound	Source Plant	Model	Treatment	Remarks	Reference
Adaptive responses of mitochondria	Berberine	Coptidis rhizome, Hydrastis canadensis	Rat	10 μM	Berberine exerts mitohormesis activity	[44]
	Polyphenol	Ribes nigrum	Mice	200 mg/kg	Polyphenol increases homeostasis and mitochondrial biogenesis	[46]
	Curcumin	Curcuma longa	Rat	15 mg/kg	The low dose was effective	[47]
	Curcumin with hesperidin	Curcuma longa	Rat	Curcumin (50, 100 mg/kg), hesperidin (10, 25 mg/kg)	Both compounds improve mitochondrial enzymes and reduce apoptosis	[48]
	Resveratrol	Ribes nigrum	Mice	10 mg/kg	Resveratrol exerts mitohormesis activity	[51]

ISSN: 1742-4933