Table 1 Characteristics and experimental measurements
Age Groups (years) | ||||||
|---|---|---|---|---|---|---|
All Volunteers | 18-33 | 34-49 | 50-66 | Significance | ||
[n] | 349 | 123 | 115 | 111 | ||
Male/Female | [n] | 166/183 | 59/64 | 57/58 | 50/61 | |
Age | [years] | 40.3 (18-66) | 22.8 (18-26) | 33.4 (27-39) | 46.5 (40-52) | |
BMI | [kg/m2] | 27.1 (18.0-43.3) | 26.6 (18.2-40.0) | 27.1 (18.0-43.3) | 27.8 (18.3-42.2) | NS |
total WBC | [103/uL] | 5.4 (2.3-8.8) | 5.9 (2.8-14.4)a | 5.6 (2.5-9.4)a | 5.2 (2.5-8.3)b | P<0.0001 |
total monocytes | [103/uL] | 0.41 (0.1-0.9) | 0.45 (0.2-0.9)a | 0.41 (0.2-0.8)ab | 0.39 (0.2-0.8)b | P=0.0027 |
TGs | [mg/dL] | 95.8 (30-421) | 83.4 (30-226)a | 105.0 (36-421)b | 99.8 (39-219)b | P=0.0004 |
Cholesterol | [mg/dL] | 174.7 (88.5-316.8) | 159.6 (88.5-261.6)a | 175.7 (118.8-263.1)b | 190.0 (108.6-316.8)c | P<0.0001 |
HDL-C | [mg/dL] | 55.4 (23.8-116.0) | 55.0 (27.5-109.4) | 53.7 (23.8-108.3) | 57.5 (27.9-116.0) | NS |
LDL-C | [mg/dL] | 109.8 (45.8-226.0) | 96.5 (45.8-182.4)a | 111.1 (65.8-200.8)b | 123.0 (62.2-226.0)c | P<0.0001 |
Insulin | [mg/dL] | 60.3 (9.6-284.2) | 65.4 (12.0-252.2) | 60.2 (12.0-284.2) | 54.7 (9.6-245.3) | NS |
Glucose | [mg/dL] | 94.7 (62.4-322.6) | 91.1 (62.4-139.5)a | 96.4 (77.8-322.6)b | 96.6 (78.1-138.2)b | P<0.0001 |
Creatinine | [μM] | 68.5 (38.2-128.8) | 68.9 (38.3-107.3) | 69.1 (45.3-112.2) | 67.3 (38.2-128.8) | NS |
IL-6 | [pg/mL] | 0.70 (0.03-3.80) | 0.61 (0.12-3.80)a | 0.67 (0.03-2.38)ab | 0.81 (0.24-3.02)b | P=0.0005 |
TNF | [pg/mL] | 2.17 (0.35-7.90) | 1.96 (0.35-5.55)a | 2.14 (0.75-4.84)ab | 2.43 (0.81-7.90)b | P<0.0001 |
IL-8 | [pg/mL] | 4.20 (0.54-27.81) | 3.68 (1.78-14.68)a | 3.93 (0.54-8.26)a | 5.04 (1.97-27.81)b | P<0.0001 |
IL-1β | [pg/mL] | 0.08 (0.00-1.18) | 0.07 (0.00-1.18)a | 0.08 (0.01-0.26)b | 0.08 (0.00-0.30)ab | P=0.0122 |
IL-10 | [pg/mL] | 0.40 (0.08-23.86) | 0.29 (0.08-2.17)a | 0.39 (0.09-6.03)b | 0.54 (0.11-23.86)ab | P=0.0331 |
CRP | [pg/mL] | 3794 (50-75352) | 3951 (62-75352) | 3644 (50-40854) | 3777 (54-32686) | NS |
SAA1 | [pg/mL] | 9059 (184-252354) | 10330 (263-252354) | 6918 (184-135584) | 9734 (245-213860) | NS |
CCL2 | [pg/mL] | 100.7 (39.1-738.4) | 94.3 (39.1-333.7)a | 91.8 (44.6-216.6)a | 116.8 (49.5-738.4)b | P<0.0001 |
Neopterin | [nM] | 6.43 (2.39-31.48) | 6.02 (2.74-19.25)a | 6.45 (2.39-15.58)b | 6.88 (3.86-31.48)b | P=0.0005 |
Myeloperoxidase | [ng/mL] | 47.7 (9.4-412.9) | 44.4 (9.4-385.6) | 50.9 (11.1-412.9) | 48.1 (18.7-303.9) | NS |