Fig. 4

Mean (± SEM) principal component (PC) scores for doublecortin (DCX) in the dorsal and ventral hippocampus, ventral hippocampus (VHPC) cytokine/chemokine levels, and basolateral amygdala (BLA) cytokine/chemokine levels. PC1 scores (A), associated with hippocampal DCX and VHPC cytokines compared to BLA cytokines, found higher hippocampal DCX and VHPC cytokine/chemokine levels in adolescent males compared to adolescent females and in adolescents compared to adult groups. Further BLA cytokines/chemokines were higher in middle-aged rats compared to young rats. @indicates p < 0.00014: comparison between each age group, *indicates p < 0.006: compared to adolescent females. PC2 scores (B), associated with VHPC and BLA cytokine/chemokine levels, were more involved in young adult females compared to young adult males. *indicates p < 0.005: compared to young adult males. n = 8–11 per sex/age. SEM = standard error of the mean