Table 1 B cell subtypes and characteristics
From: Antibodies in action: the role of humoral immunity in the fight against atherosclerosis
| Â | B-1 Cells | B-2 Cells | B-2 Cells |
|---|---|---|---|
Subset | B-1a, B-1b | Marginal zone (MZ) | Follicular (FO) |
Location | Peritoneal cavity, spleen | Spleen, lymph node | Spleen, lymph node |
Major Ig | IgM, IgA | IgM | IgM, IgG, IgA, IgE |
V Genes | Limited V-gene repertoire | Limited V-gene repertoire | Diverse V-gene repertoire |
V Gene Mutations | Non-mutated V-genes | Low mutated V-genes | High mutated V-genes (Increased Affinity) |