Fig. 1

miRs mediate differential gene expression related to obesity and associated MS. miRs act on NF-κB, TLR, IL, and PI3K/AKT signaling pathways. miR-214 inhibits DPP4 that further activates the translocation of NF-κB. miR-146 inhibits TRAF6 and blocks the downstream signaling. miR-155 inhibits SOCS-1, which blocks the activity of the JAK/STAT pathway. Additionally, miR-155 along with miR-34a inhibits SIRT1 signaling and that is associated with numerous biological activities, including inhibition of NF-κB transcription factor, increasing mitochondria biogenesis by positively regulating PGC-1α. miR-182 inhibits transcriptional factor C/EBPα, which further inhibits adipogenesis. All these suggest the role of miRs in differential gene expression during obesity