Table 1 Human IL-7 receptor alpha (IL-7Rα) high and low effector memory* CD8+ T cells have distinct cellular characteristics
|  | IL-7Rαhigh cells | IL-7Rαlow cells |
|---|---|---|
CD27 and CD28 expression | High | Low |
CD57 expression | Low | High |
Perforin, granzyme B | Low | High |
T cell receptor (TCR) repertoire | Diverse | Limited |
TCR-mediated proliferation | High | Low |
IFN-γ and TNF-α production | Low | High |
IL-7 survival response | High | Low |
IL-15-mediated proliferation | Low | High |
IL7R gene expression | High | Low |
DNA Methylation in IL7R promoter | Low | High |
CX3CR1 (fractalkine receptor) expression | Low | High |
DNA Methylation in CX3CR1 promoter | High | Low |
Aging | Low | High |