Fig. 1
From: Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults
COVID-19 Impact on Antibody Response in Older Adults. ELISA was performed on patient samples for antibodies to spike IgG over the vaccine study time course: Dose 1 (baseline), Dose 2 (28 days), 2-weeks post vaccine dose 2 (2w pd2), 3-months (3 m pd2), and 6-months (6 m pd2); Boost, and 2-weeks post boost (2w pb). Over the vaccine time course, Spike IgG antibody titers were 16-fold higher in individuals with prior COVID-19 infection than uninfected (Sero-Naïve) p < 0.001. After the booster, titers increased in all individuals but were no longer associated w/ prior infection (p = 0.82)