Fig. 8

Nasal administration of MSC reverses cognitive impairment induced by cisplatin. Mice were treated with cisplatin and MSC and performance in the puzzle box test (A and B) and NOPRT (C and D) was assessed starting 6 weeks after MSC administration. Data for the puzzle box test represent time in seconds needed to enter the dark compartment during the hard trials for males (A) and females (B). Performance in the NOPRT for males (C) and females (D) is presented as discrimination index: (Time _Novel – Time _Familiar)/(Time _Novel + Time _Familiar). Results are expressed as mean ± SEM of n = 8 mice/group collected in two independent cohorts; ^* p < 0.05; ^****p < 0.0001.