Fig. 5

EV mtDNA levels are correlated with EV inflammatory proteins. Pearson correlation using pairwise complete observation was used to determine the associations between the four EV mtDNA amplicon regions and EV inflammatory proteins. Color is based on correlation coefficient (r), where r = 1 is red and r = − 1 is blue. Significance of the p-value is shown by size of the circle for each correlation. A p-value of 0.05 was used as the threshold for significance. Degree of significance is denoted by circle size. The four mitochondrial primer sets are denoted by “Mito_X”