Skip to main content

Table 2 Hemagglutination Inhibition (HAI) antibody titers after trivalent adjuvanted inactivated influenza vaccine (aIIV3) and trivalent high-dose inactivated influenza vaccine (HD-IIV3) for each influenza vaccine strain by season(s) 2017–2018 and 2018–2019 influenza seasons. 2017–2018 and 2018–1019 influenza seasons

From: Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial

 

aIIV3

HD-IIV3

aIIV3–HD-IIV3

Strain

 

Time

N

Value

95% CI

N

Value

95% CI

Difference 95% CI

2017–2018 and 2018–1019 influenza seasons

 H1N1

GMTc

Day 1f

342

51.8

(44.5, 60.3)

338

50.8

(43.4, 59.4)

0.01 (-0.09, 0.10)

 

Day 29

342

100.0

(86.6, 115.6)

338

98.0

(84.6, 113.6)

0.01 (-0.08, 0.10)

%SPd

Day 1

238

69.6

(64.4, 74.4)

226

66.9

(61.6, 71.8)

2.73 (-4.27, 9.72)

 

Day 29

285

83.3

(79.0, 87.1)

282

83.4

(79.0, 87.2)

-0.10 (-5.69, 5.50)

%SCe

Day 29

96

28.1

(23.4, 33.2)

90

26.6

(22.0, 31.7)

1.44 (-5.26, 8.14)

 H3N2

GMT

Day 1

342

63.4

(52.8, 76.1)

338

58.5

(48.4, 70.7)

0.03 (-0.08, 0.15)

 

Day 29

342

141.7

(123.2, 162.9)

338

177.3

(152.7, 205.9)

-0.10 (-0.19, -0.01)

%SP

Day 1

228

66.7

(61.4, 71.6)

222

65.7

(60.4, 70.7)

0.99 (-6.13, 8.10)

 

Day 29

307

89.8

(86.1, 92.7)

299

88.5

(84.6, 91.6)

1.30 (-3.38, 5.99)

%SC

Day 29

112

32.7

(27.8, 38.0)

130

38.5

(33.2, 43.9)

-5.71 (-12.90, 1.47)

 Influenza B

GMT

Day 1

342

13.4

(11.9, 15.0)

338

14.7

(12.9, 16.7)

-0.04 (-0.11, 0.03)

 

Day 29

342

21.6

(18.5, 25.2)

338

27.5

(23.5, 32.3)

-0.11 (-0.20, -0.01)

%SP

Day 1

84

24.6

(20.1, 29.5)

91

26.9

(22.3, 32.0)

-2.36 (-8.93, 4.21)

 

Day 29

151

44.2

(38.8, 49.6)

165

48.8

(43.4, 54.3)

-4.66 (-12.15, 2.83)

%SC

Day 29

64

18.7

(14.7, 23.3)

79

23.4

(19.0, 28.3)

-4.66 (-10.78, 1.46)

2017–2018 influenza seasona

 H1N1

GMTc

Day 1f

123

29.2

(23.7, 36.0)

122

29.3

(23.6, 36.5)

-0.00 (-0.13, 0.13)

 

Day 29

123

88.7

(68.5, 114.8)

122

88.6

(67.6, 116.2)

0.00 (-0.16, 0.16)

%SPd

Day 1

61

49.6

(40.5, 58.7)

59

48.4

(39.2, 57.5)

1.23 (-11.29, 13.75)

 

Day 29

96

78.0

(69.7, 84.9)

100

82.0

(74.0, 88.2)

-3.92 (-13.92, 6.08)

%SCe

Day 29

47

38.2

(29.6, 47.4)

52

42.6

(33.7, 51.9)

-4.41 (-16.69, 7.87)

 H3N2

GMT

Day 1

123

69.7

(53.2, 91.3)

122

78.7

(59.5, 104)

-0.05 (-0.22, 0.11)

 

Day 29

123

228.2

(178.7, 291.4)

122

281.6

(213.6, 371.3)

-0.09 (-0.25, 0.07)

%SP

Day 1

84

68.3

(59.3, 76.3)

87

71.3

(62.4, 79.1)

-3.02 (-14.51, 8.47)

 

Day 29

117

95.1

(89.7, 98.0)

108

88.5

(81.5, 93.4)

6.60 (-0.22, 13.41)

%SC

Day 29

55

44.7

(35.7, 53.9)

54

44.3

(35.3, 53.5)

0.45 (-11.99, 12.90)

 Influenza B

GMT

Day 1

123

19.2

(15.9, 23.3)

122

18.9

(15.3, 23.4)

0.01 (-0.12, 0.13)

 

Day 29

123

27.3

(21.5, 34.6)

122

37.6

(29.3, 48.3)

-0.14 (-0.29, 0.01)

%SP

Day 1

43

35.0

(26.6, 44.1)

44

36.1

(27.6, 45.2)

-1.11 (-13.09, 10.88)

 

Day 29

62

50.4

(41.2, 59.5)

74

60.7

(51.4, 69.3)

-10.25 (-22.63, 2.13)

%SC

Day 29

19

15.4

(9.6, 23.1)

29

23.8

(16.5, 32.3)

-8.32 (-18.22, 1.57)

2018–2019 influenza seasonb

 H1N1

GMTc

Day 1f

219

71.5

(58.9, 86.8)

216

69.2

(56.5, 84.8)

0.01 (-0.11, 0.14)

 

Day 29

219

107.0

(89.9, 127.5)

216

103.7

(87.1, 123.5)

0.01 (-0.09, 0.12)

%SPd

Day 1

177

80.8

(75.0, 85.8)

167

77.3

(71.1, 82.7)

3.51 (-4.13, 11.15)

 

Day 29

189

86.3

(81.0, 90.5)

182

84.3

(78.7, 88.8)

2.04 (-4.62, 8.70)

%SCe

Day 29

49

22.4

(17.0, 28.5)

38

17.6

(12.8, 23.3)

4.78 (-2.72, 12.28)

 H3N2

GMT

Day 1

219

60.1

(47.1, 76.7)

216

49.5

(38.6, 63.5)

0.08 (-0.07, 0.23)

 

Day 29

219

108.4

(92.3, 127.3)

216

136.5

(115.6, 161.2)

-0.10 (-0.20, -0.00)

%SP

Day 1

144

65.8

(59.1, 72.0)

135

62.5

(55.7, 68.9)

3.25 (-5.76, 12.26)

 

Day 29

190

86.8

(81.5, 90.9)

191

88.4

(83.4, 92.3)

-1.67 (-7.86, 4.53)

%SC

Day 29

57

26.0

(20.3, 32.4)

76

35.2

(28.8, 41.9)

-9.16 (-17.78, -0.54)

 Influenza B

GMT

Day 1

219

10.9

(9.5, 12.5)

216

12.8

(10.9, 15.0)

-0.07 (-0.16, 0.02)

 

Day 29

219

19.0

(15.6, 23.1)

216

23.1

(18.9, 28.3)

-0.09 (-0.21, 0.04)

%SP

Day 1

41

18.7

(13.8, 24.5)

47

21.8

(16.4, 27.9)

-3.04 (-10.59, 4.51)

 

Day 29

89

40.6

(34.1, 47.5)

91

42.1

(35.5, 49.0)

-1.49 (-10.75, 7.77)

%SC

Day 29

45

20.5

(15.4, 26.5)

50

23.1

(17.7, 29.3)

-2.60 (-10.36, 5.16)

  1. aVirus strains H1N1: A/Michigan/45/2015 (H1N1) pdm09-like virus; H3N2: A/Hong Kong /4801/2014 (H3N2)-like virus; B: B/Brisbane/60/2008-like virus (Victoria lineage)
  2. bVirus strains H1N1: A/Michigan/45/2015 (H1N1)pdm09-like virus; H3N2: A/Singapore/INFIMH-16–0019/2016 A(H3N2)-like virus; B: B/Colorado/06/2017-like virus (Victoria lineage)
  3. cGMT: Geometric mean titers
  4. d%SP: Percent Seropositive, defined as HAI titer ≥ 1:40
  5. e%SC: Percent Seroconversion, defined as an HAI titer ≥ 1:40 at day 29 post-vaccination if the baseline pre-vaccination titer is < 1:10 or a minimum four-fold rise in HAI titer if the baseline pre-vaccination titer is ≥ 1:10
  6. fDay 1: Baseline blood draw before vaccination; Day 29 blood draw on 29 ± 7 days post-vaccination
Back to article page

Immunity & Ageing

ISSN: 1742-4933

Contact us