Table 3 Hemagglutination Inhibition (HAI) antibody titers after trivalent adjuvanted inactivated influenza vaccine (aIIV3) and trivalent high-dose inactivated influenza vaccine (HD-IIV3) for each influenza vaccine strain by age for 2017–2018 and 2018–2019 influenza seasons
65–79 Years | |||||||||
|---|---|---|---|---|---|---|---|---|---|
aIIV3 Group | HD-IIV3 Group | aIIV3–HD-IIV3 | |||||||
Strain | Time | N | Value | 95% CI | N | Value | 95% CI | Difference 95% CI | |
H1N1 | GMTa | Day 1d | 269 | 52.5 | (44.3, 62.2) | 261 | 49.5 | (41.4, 59.0) | 0.03 (-0.08, 0.13) |
Day 29 | 269 | 108.8 | (92.1, 128.5) | 261 | 100.9 | (84.9, 119.9) | 0.03 (-0.07, 0.14) | ||
%SPb | Day 1 | 188 | 69.9 | (64.0, 75.3) | 171 | 65.5 | (59.4, 71.2) | 4.37 (-3.59, 12.33) | |
Day 29 | 225 | 83.6 | (78.7, 87.8) | 216 | 82.8 | (77.6, 87.1) | 0.88 (-5.48, 7.25) | ||
%SCc | Day 29 | 80 | 29.7 | (24.3, 35.6) | 71 | 27.2 | (21.9, 33.0) | 2.54 (-5.14, 10.22) | |
H3N2 | GMT | VDay 1 | 269 | 63.3 | (51.7, 77.5) | 261 | 56.4 | (45.5, 69.8) | 0.05 (-0.08, 0.18) |
Day 29 | 269 | 145.3 | (124.3, 169.7) | 261 | 184.4 | (155.2, 219.1) | -0.10 (-0.20, -0.00) | ||
%SP | Day 1 | 181 | 67.3 | (61.3, 72.8) | 171 | 65.5 | (59.4, 71.2) | 1.77 (-6.27, 9.81) | |
Day 29 | 246 | 91.4 | (87.4, 94.4) | 230 | 88.1 | (83.6, 91.7) | 3.33 (-1.83, 8.48) | ||
%SC | Day 29 | 92 | 34.2 | (28.5, 40.2) | 103 | 39.5 | (33.5, 45.7) | -5.26 (-13.47, 2.94) | |
Influenza B | GMT | Day 1 | 269 | 12.2 | (10.8, 13.8) | 261 | 11.8 | (10.3, 13.4) | 0.02 (-0.06, 0.09) |
Day 29 | 269 | 20.3 | (17.2, 24.1) | 261 | 23.8 | (20.0, 28.4) | -0.07 (-0.17, 0.04) | ||
%SP | Day 1 | 60 | 22.3 | (17.5, 27.8) | 52 | 19.9 | (15.3, 25.3) | 2.38 (-4.56, 9.33) | |
Day 29 | 114 | 42.4 | (36.4, 48.5) | 118 | 45.2 | (39.1, 51.5) | -2.83 (-11.28, 5.61) | ||
%SC | Day 29 | 51 | 19.0 | (14.5, 24.2) | 68 | 26.1 | (20.8, 31.8) | -7.09 (-14.19, -0.00) | |
80 years and older | |||||||||
H1N1 | GMTa | Day 1d | 73 | 49.3 | (35.1, 69.3) | 77 | 55.6 | (39.2, 78.8) | -0.05 (-0.26, 0.16) |
Day 29 | 73 | 73.4 | (55.2, 97.7) | 77 | 88.7 | (66.7, 118.0) | -0.08 (-0.25, 0.09) | ||
%SPb | Day 1 | 50 | 68.5 | (56.6, 78.7) | 55 | 71.4 | (60.0, 81.0) | -2.94 (-17.61, 11.74) | |
Day 29 | 60 | 82.2 | (71.5, 89.9) | 66 | 85.7 | (75.9, 92.4) | -3.52 (-15.27, 8.23) | ||
%SCc | Day 29 | 16 | 21.9 | (13.1, 33.1) | 19 | 24.7 | (15.6, 35.8) | -2.76 (-16.28, 10.76) | |
H3N2 | GMT | Day 1 | 73 | 63.7 | (41.4, 98.0) | 77 | 66.5 | (43.9, 101) | -0.02 (-0.27, 0.24) |
Day 29 | 73 | 129.2 | (93.4, 178.8) | 77 | 155.0 | (114.2, 210.5) | -0.08 (-0.27, 0.11) | ||
%SP | Day 1 | 47 | 64.4 | (52.3, 75.1) | 51 | 66.2 | (54.6, 76.5) | -1.85 (-17.09, 13.39) | |
Day 29 | 61 | 83.6 | (73.0, 91.0) | 69 | 89.6 | (80.6, 95.2) | -6.05 (-16.95, 4.85) | ||
%SC | Day 29 | 20 | 27.4 | (17.6, 39.1) | 27 | 35.1 | (24.5, 46.7) | -7.67 (-22.44, 7.11) | |
Influenza B | GMT | Day 1 | 73 | 18.7 | (14.6, 24.0) | 77 | 31.2 | (23.2, 42.1) | -0.22 (-0.39, -0.05) |
Day 29 | 73 | 27.0 | (19.0, 38.2) | 77 | 45.0 | (31.8, 63.5) | -0.22 (-0.43, -0.01) | ||
%SP | Day 1 | 24 | 32.9 | (22.3, 44.8) | 39 | 50.6 | (39.0, 62.2) | -17.77 (-33.29, -2.25) | |
Day 29 | 37 | 50.7 | (38.7, 62.5) | 47 | 61.0 | (49.2, 71.8) | -10.35 (-26.17, 5.46) | ||
%SC | Day 29 | 13 | 17.8 | (9.8, 28.5) | 11 | 14.3 | (7.4, 24.1) | 3.52 (-8.23, 15.27) | |