Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

Table 4 Mediation effect of low-grade inflammation on the association of movement behaviors with plasma NfL concentration (n = 991)

Parameters from mediation models	Estimated β-coefficient (95% confidence interval)
Association of SB with plasma NfL
Total effect	0.033 (0.015, 0.052)^‡
Mediation effect by inflammation score	0.005 (0.002, 0.010)^‡
Direct effect	0.028 (0.010, 0.047)^†
Proportion mediated	0.161 (0.064, 0.396)^‡
Association of LPA with plasma NfL
Total effect	-0.038 (-0.065, -0.014)^†
Mediation effect by inflammation score	-0.007 (-0.013, -0.003)^‡
Direct effect	-0.031 (-0.057, -0.008)^*
Proportion mediated	0.178 (0.061, 0.484)^†
Association of MVPA with plasma NfL
Total effect	-0.061 (-0.097, -0.027)^‡
Mediation effect by inflammation score	-0.009 (-0.018, -0.003)^†
Direct effect	-0.052 (-0.087, -0.016)^†
Proportion mediated	0.145 (0.041, 0.371)^†

Mediation analysis was adjusted for age, sex, education, and wear seasons and daily wear time of ActiGraph
Abbreviations: SB Sedentary behavior, LPA Light physical activity, MVPA Moderate-to-vigorous intensity physical activity, NfL Neurofilament light chain
^*P < 0.05, ^†P < 0.01, ^‡P < 0.001

ISSN: 1742-4933