Fig. 4

The effects of high plasma Aβ_1-42 on phagocytic ability of macrophages. a The phagocytic ability of macrophages in Wt, Tg, PaWt(Wt-Wt), and PaWt(Wt-Tg) mice. Macrophages were stained with CD11b⁺F4/80.⁺. b The statistical diagram of phagocytic ability of macrophages in Wt, Tg, PaWt(Wt-Wt), and PaWt(Wt-Tg) mice. At the age of 7 months, the macrophage phagocytosis Aβ_1-42 in Tg mice were decreased significantly compared with Wt mice (p = 0.002). There is no statistical difference in macrophage phagocytosis Aβ_1-42 compared Tg with Wt mice at the age of 11 months (p = 0.819). After parabiosis for 4 and 8 months, the macrophage phagocytosis Aβ_1-42 had no obvious alteration (after parabiosis for 4 months p = 0.062, after parabiosis for 8 months p = 0.494). c The phagocytic ability of macrophages after co-cultured with Aβ_1-42 peptide in vitro. The phagocytosis of macrophages was significantly reduced after co-cultured with Aβ_1-42 peptide in vitro for 3 days (p = 0.032) (c). (n = 6, Mean ± SD, one-way analysis of variance. *P < 0.05, ns denotes no statistical significance)