Fig. 3

Impact of sex, age, and their interaction on adverse event (AE) reporting. The estimated probabilities of reporting of any adverse event (AE) (A), any local AE (B), and any systemic AE (C) are shown for males and females. Probabilities were estimated using mixed effects regression models to account for repeat measurements on individuals over the four influenza seasons and control for age at vaccination. Using similar models, but controlling for sex, the change in the probability of reporting an AE with age is shown (D-F). Expanded models with an interaction term between age and sex were then used to assess the effect of age separately for males and females (G-I).